PMID- 19760589
OWN - NLM
STAT- MEDLINE
DCOM- 20091216
LR  - 20170220
IS  - 1699-5848 (Electronic)
IS  - 0213-3911 (Linking)
VI  - 24
IP  - 11
DP  - 2009 Nov
TI  - FOXP1 status in splenic marginal zone lymphoma: a fluorescence in situ 
      hybridization and immunohistochemistry approach.
PG  - 1399-404
LID - 10.14670/HH-24.1399 [doi]
AB  - Splenic marginal zone lymphoma (SMZL) is a well-recognized entity in which 
      chromosomal aberrations seem to be potential markers in diagnosis, prognosis and 
      disease monitoring. FOXP1 is a transcriptional regulator of B lymphopoiesis that 
      is deregulated in some types of NHL. Translocation t(3;14)(p14;q32) has been 
      described in marginal zone lymphomas but few series have studied FOXP1 
      involvement in SMZL. We performed cytogenetic, fluorescence in situ hybridization 
      (FISH) and immunohistochemical (IHC) studies in a series of 36 patients in order 
      to study the status of FOXP1 in this entity. According to our results, FOXP1 is 
      not rearranged in SMZL, although we were able to demonstrate gains of FOXP1 gene 
      due to trisomy 3/3p by FISH. FOXP1 protein expression seemed to be not related to 
      any aberration and IHC studies are not conclusive.
FAU - Baro, Cristina
AU  - Baro C
AD  - Dept. Biologia Animal, Vegetal i Ecologia. Unitat d'Antropologia Biologica. 
      Facultat de Biociencies. Universitat Autonoma de Barcelona, Bellaterra, 
      Barcelona, Spain.
FAU - Espinet, Blanca
AU  - Espinet B
FAU - Salido, Marta
AU  - Salido M
FAU - Colomo, Lluis
AU  - Colomo L
FAU - Luno, Elisa
AU  - Luno E
FAU - Florensa, Lourdes
AU  - Florensa L
FAU - Ferrer, Ana
AU  - Ferrer A
FAU - Salar, Antonio
AU  - Salar A
FAU - Campo, Elias
AU  - Campo E
FAU - Serrano, Sergi
AU  - Serrano S
FAU - Sole, Francesc
AU  - Sole F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Spain
TA  - Histol Histopathol
JT  - Histology and histopathology
JID - 8609357
RN  - 0 (FOXP1 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Repressor Proteins)
SB  - IM
MH  - Forkhead Transcription Factors/biosynthesis/*genetics
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, B-Cell, Marginal Zone/*genetics/metabolism
MH  - Repressor Proteins/biosynthesis/*genetics
MH  - Splenic Neoplasms/*genetics/metabolism
EDAT- 2009/09/18 06:00
MHDA- 2009/12/17 06:00
CRDT- 2009/09/18 06:00
PHST- 2009/09/18 06:00 [entrez]
PHST- 2009/09/18 06:00 [pubmed]
PHST- 2009/12/17 06:00 [medline]
AID - 10.14670/HH-24.1399 [doi]
PST - ppublish
SO  - Histol Histopathol. 2009 Nov;24(11):1399-404. doi: 10.14670/HH-24.1399.