PMID- 19761533
OWN - NLM
STAT- MEDLINE
DCOM- 20100517
LR  - 20221207
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 6
DP  - 2009 Dec
TI  - Distribution of killer-cell immunoglobulin-like receptor genes in Eastern 
      mainland Chinese Han and Taiwanese Han populations.
PG  - 499-507
LID - 10.1111/j.1399-0039.2009.01366.x [doi]
AB  - The interaction between killer-cell immunoglobulin-like receptors (KIRs) and 
      human leukocyte antigen (HLA) molecules expressed on target cells is known to 
      modulate the cytolytic activity of natural killer (NK) cells. To date, a wide 
      range of KIR genotypes has been observed, which varies among different ethnic 
      populations. We report here comparison of the KIR gene content and genotypic 
      structure of KIRs in 106 individuals from Eastern mainland Chinese Han and 97 
      from Taiwanese Han. All 17 KIR genes were observed in the two populations. 
      Framework genes 2DL4, 3DL2, 3DL3 and 3DP1 were present in all individuals. The 
      two populations had very similar frequencies in most loci, however, significant 
      differences were noted in the frequencies of KIR3DS1 and KIR2DS4D (KIR2DS4 
      deletant variant). A total of 35 and 29 genotypes were identified in the 
      individuals from the Eastern mainland Chinese and the Taiwanese Hans, 
      respectively. Some pairs of KIRs showed significant positive and negative linkage 
      disequilibrium (LD). Our data showed that there were minor distinctions in KIR 
      gene frequencies, genotypes and LD between the two populations, which shed light 
      on a possible geographic genetic demarcation among different Chinese communities.
FAU - Wu, G-Q
AU  - Wu GQ
AD  - Bone Marrow Transplantation Center, School of Medicine, The First Affiliated 
      Hospital of Zhejiang University Medical School, Hangzhou, China.
FAU - Zhao, Y-M
AU  - Zhao YM
FAU - Lai, X-Y
AU  - Lai XY
FAU - Yang, K-L
AU  - Yang KL
FAU - Zhu, F-M
AU  - Zhu FM
FAU - Zhang, W
AU  - Zhang W
FAU - Wang, W
AU  - Wang W
FAU - Luo, Y
AU  - Luo Y
FAU - Tan, Y-M
AU  - Tan YM
FAU - Wang, Y-J
AU  - Wang YJ
FAU - Cao, W-J
AU  - Cao WJ
FAU - Huang, H
AU  - Huang H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090917
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA Antigens)
RN  - 0 (KIR2DS4 protein, human)
RN  - 0 (Receptors, KIR)
SB  - IM
MH  - Asian People/*genetics
MH  - China/ethnology
MH  - Genotype
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Receptors, KIR/*genetics
MH  - Taiwan/ethnology
EDAT- 2009/09/19 06:00
MHDA- 2010/05/18 06:00
CRDT- 2009/09/19 06:00
PHST- 2009/09/19 06:00 [entrez]
PHST- 2009/09/19 06:00 [pubmed]
PHST- 2010/05/18 06:00 [medline]
AID - TAN1366 [pii]
AID - 10.1111/j.1399-0039.2009.01366.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Dec;74(6):499-507. doi: 10.1111/j.1399-0039.2009.01366.x. 
      Epub 2009 Sep 17.