PMID- 1976425
OWN - NLM
STAT- MEDLINE
DCOM- 19901106
LR  - 20181130
IS  - 0764-4469 (Print)
IS  - 0764-4469 (Linking)
VI  - 311
IP  - 2
DP  - 1990
TI  - [Implication of alpha-2 adrenergic post-synaptic receptors in the central 
      catecholaminergic stimulation of the corticotropic axis in rats].
PG  - 81-8
AB  - We have recently assigned a major stimulatory role to the brain catecholamines 
      (CA) via alpha 1 and beta receptors on CRH-ACTH secretion, e.g. in the 
      physiological response to stress. In the present study, we explored the possible 
      participation in this regulation of post-synaptic alpha 2 receptors in free 
      moving rats, one week after CA denervation of the hypothalamus by bilateral 
      neurotoxic lesions of the noradrenergic ascending brain stem bundles (NAB). 
      Intracerebroventricular (i.c.v.) injection of clonidine (alpha 2 agonist; 1 nmol) 
      induced a 3 fold rise of ACTH release (measured by RIA) above vehicle (PBS) 
      injected controls (p less than 0.001). This stimulatory effect was completely 
      reversed by an i.c.v. pretreatment with the alpha 2 antagonist idazoxan (10 nmol; 
      without action by itself), whereas it was only slightly affected by an i.c.v. 
      pretreatment with a combination of an alpha 1 and beta blocker (prazosin + 
      propranolol; 5/5 nmol; p greater than 0.1). The results strongly suggest the 
      participation of alpha 2 post-synaptic receptors in the central catecholaminergic 
      activation of ACTH secretion.
FAU - Szafarczyk, A
AU  - Szafarczyk A
AD  - U.R.A. 1197-C.N.R.S., Departement de Biologie-Sante, Universite de Montpellier-2.
FAU - Gaillet, S
AU  - Gaillet S
FAU - Barbanel, G
AU  - Barbanel G
FAU - Malaval, F
AU  - Malaval F
FAU - Assenmacher, I
AU  - Assenmacher I
LA  - fre
PT  - Journal Article
TT  - Implication des recepteurs alpha 2 adrenergiques post-synaptiques dans la 
      stimulation catecholaminergique centrale de l'axe corticotrope chez le rat.
PL  - France
TA  - C R Acad Sci III
JT  - Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie
JID - 8503078
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Dioxanes)
RN  - 0 (Receptors, Adrenergic, alpha)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
RN  - 9Y8NXQ24VQ (Propranolol)
RN  - MN3L5RMN02 (Clonidine)
RN  - XM03YJ541D (Prazosin)
RN  - Y310PA316B (Idazoxan)
SB  - IM
MH  - Adrenergic alpha-Antagonists/administration & dosage/pharmacology
MH  - Adrenocorticotropic Hormone/*metabolism
MH  - Animals
MH  - Clonidine/administration & dosage/pharmacology
MH  - Depression, Chemical
MH  - Dioxanes/administration & dosage/pharmacology
MH  - Drug Therapy, Combination
MH  - Female
MH  - Idazoxan
MH  - Injections, Intraventricular
MH  - Prazosin/administration & dosage/pharmacology
MH  - Propranolol/administration & dosage/pharmacology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Adrenergic, alpha/*physiology
MH  - Stimulation, Chemical
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - C R Acad Sci III. 1990;311(2):81-8.