PMID- 19764578
OWN - NLM
STAT- MEDLINE
DCOM- 20100330
LR  - 20090921
IS  - 1672-173X (Print)
IS  - 1672-173X (Linking)
VI  - 40
IP  - 4
DP  - 2009 Jul
TI  - [Glycemic excursions in people with normal glucose tolerance in Chengdu].
PG  - 704-7
AB  - OBJECTIVE: To investigate the characteristics of glycemic excursions in people 
      with normal glucose tolerance (NGT) in Chengdu. METHODS: A total of 50 non-obese 
      people with normal glucose tolerance (NGT, 23-68 years old), normal blood 
      pressures and lipid profiles participated in the study. The fluctuations of 
      glucose levels in the participants were measured by a continuous glucose 
      monitoring system (CGMS) for three days 72 h. The 48 h mean blood glucose (MBG), 
      mean amplitude of glycemic excursions (MAGE), Largest amplitude of glycemic 
      excursions (LAGE), Postprandial peak glucose (PPG), Postprandial glucose 
      excursion (PPGE), Mean of postprandial glucose excursion (MPPGE), and absolute 
      means of daily differences (MODD) were measured. RESULTS: The number of glucose 
      values detected by CGMS amounted to 861+/-7 with a mean absolute difference (MAD) 
      of 11.3%+/-10.6%. The CGMS values were significantly correlated with the 
      capillary glucose measurements (n=1076, r=0.761, P<0.005). The participants had a 
      MBG of (5.9+/-1.2) mmol/L, a MAGE of (1.7+/-0.7) mmol/L, a LAGE of (4.4+/-1.9) 
      mmol/L, a daily glycemic peak (PPG) of (8.7+/-1.7) mmol/L, a nadir level of 
      (4.3+/-0.7) mmol/L, a MPPGE of (2.3+/-1.6) mmol/L, and a MODD of (0.75+/-0.79) 
      mmol/L. The post-breakfast Postprandial glycemic excursions (PPGE) were lower 
      than those of post-lunch and post-dinner (P=0.01 and P=0.05). The postprandial 
      glucose excursions in the 60-70 year-old participants were the highest (P<0.022). 
      In 95% (77%-100%) of the daytime, the glycose levels fluctuated between 4.1 and 
      8.8 mmol/L, and 78% of the participants (n=39) had hyperglycemia (BG>7.8 mmol/L) 
      and 10% (n=5) had asymtomatic hypoglycemia (BG<2.8 mmol/L). CONCLUSION: CGMS 
      tests may be important for detecting asymptomatic hyperglycemia and hypoglycemia. 
      The NGT people in Chengdu have exhibited abnormal blood glucose values in CGMS, 
      revealing problems in people with normal range of blood glucose.
FAU - He, Li-Ping
AU  - He LP
AD  - Department of Endocrinology and Metabolism, West China Hospital, Sichuan 
      University, Chengdu 610041, China.
FAU - Wang, Chun
AU  - Wang C
FAU - Zhong, Li
AU  - Zhong L
FAU - Yang, Yan-Zhi
AU  - Yang YZ
FAU - Long, Yang
AU  - Long Y
FAU - Zhang, Xiang-Xun
AU  - Zhang XX
FAU - Shu, Shi-Qing
AU  - Shu SQ
FAU - Yu, Hong-Ling
AU  - Yu HL
FAU - Yu, Ting-Ting
AU  - Yu TT
FAU - Wang, Wei-Ping
AU  - Wang WP
FAU - Wang, Yu
AU  - Wang Y
FAU - Ran, Xing-Wu
AU  - Ran XW
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Sichuan Da Xue Xue Bao Yi Xue Ban
JT  - Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical 
      science edition
JID - 101162609
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Glucose/*metabolism
MH  - China
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - *Glucose Tolerance Test
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Young Adult
EDAT- 2009/09/22 06:00
MHDA- 2010/03/31 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/03/31 06:00 [medline]
PST - ppublish
SO  - Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Jul;40(4):704-7.