PMID- 19765232
OWN - NLM
STAT- MEDLINE
DCOM- 20100803
LR  - 20100426
IS  - 1399-5448 (Electronic)
IS  - 1399-543X (Linking)
VI  - 11
IP  - 2
DP  - 2010 Mar
TI  - The prevalence of impaired fasting glucose and type 2 diabetes in a 
      population-based sample of overweight/obese children in the Middle East.
PG  - 101-6
LID - 10.1111/j.1399-5448.2009.00534.x [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) and impaired fasting glucose (IFG) 
      are increasing in young population who are facing an escalating trend of 
      overweight. The aim of this study was to determine the prevalence of IFG and T2DM 
      for the first time in a population-based sample of Iranian obese children. 
      METHODS: This cross-sectional, population-based study was conducted in Isfahan, 
      the second large city of Iran. Overall, 672 overweight and obese school students, 
      selected from 7554 students, aged 6-19 yr, were screened for IFG and T2DM. 
      Fasting plasma glucose (FPG) and lipid profile were measured in all participants. 
      Oral glucose tolerance test and insulin level were measured in those children 
      with IFG. Insulin resistance was defined as homeostasis model assessment for 
      insulin resistance (HOMA-IR) > 3.10. RESULTS: Among the7554 students (48.7% boys 
      and 51.3% girls) studied, 9.34% (n = 706) were overweight and 5.3% (n = 403) were 
      obese. A number of 672 overweight and obese students including 302 (44.9%) boys 
      and 370 (55.1%) girls, with a mean age of 12.8 +/- 3.10 yr underwent biochemical 
      work up. Overall, the prevalence of IFG was 4.61% (n = 31), the corresponding 
      figure was 2% (n = 4) in the 6-10 yr age group, and 5% (n = 27) in those aged 
      10.1-19 yr. The prevalence of T2DM was 0.1% (n = 1; age, 18.00 yr). Impaired 
      glucose tolerance and insulin resistance were detected in three and six 
      participants with IFG, who consisted 0.4 and 0.8% of total obese and overweight 
      students, respectively. CONCLUSIONS: Although the prevalence of T2DM is low in 
      Iranian obese children, IFG is not uncommon. Preventive measures and screening of 
      FPG should be considered for these children.
FAU - Moadab, Mohammad Hasan
AU  - Moadab MH
AD  - Department of Pediatric Endocrinology, Endocrine and Metabolism Research Center, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Kelishadi, Roya
AU  - Kelishadi R
FAU - Hashemipour, Mahin
AU  - Hashemipour M
FAU - Amini, Masoud
AU  - Amini M
FAU - Poursafa, Parinaz
AU  - Poursafa P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090918
PL  - Denmark
TA  - Pediatr Diabetes
JT  - Pediatric diabetes
JID - 100939345
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Adolescent
MH  - Blood Glucose/*metabolism
MH  - Child
MH  - Cross-Sectional Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology/physiopathology
MH  - Fasting/physiology
MH  - Female
MH  - Humans
MH  - Insulin Resistance
MH  - Iran/epidemiology
MH  - Male
MH  - Obesity/epidemiology/physiopathology
MH  - Overweight/*epidemiology/physiopathology
MH  - Prevalence
MH  - Young Adult
EDAT- 2009/09/22 06:00
MHDA- 2010/08/04 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/08/04 06:00 [medline]
AID - PDI534 [pii]
AID - 10.1111/j.1399-5448.2009.00534.x [doi]
PST - ppublish
SO  - Pediatr Diabetes. 2010 Mar;11(2):101-6. doi: 10.1111/j.1399-5448.2009.00534.x. 
      Epub 2009 Sep 18.