PMID- 19765261
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20091022
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 74
IP  - 5
DP  - 2009 Nov
TI  - Genetic determinants of HIV-1 infection and progression to AIDS: immune response 
      genes.
PG  - 373-85
LID - 10.1111/j.1399-0039.2009.01337.x [doi]
AB  - Genomic studies involving well-defined multicenter cohorts of HIV-1/AIDS covering 
      multiple populations have led to a greater understanding of the role of host 
      determinants in viral acquisition, disease progression, transmission, and 
      response to anti-retroviral therapy. Similarly, recent knowledge on the virus 
      genetic diversity has helped in elucidating mechanisms leading to the evolution 
      of viral escape mutants and the role played by host immune determinants, in 
      particular the major histocompatibility complex (MHC) associated genes. At least 
      two alleles, HLA-B*27 and B*57, have been identified as 'protective' against 
      HIV-1 while B*35 and B*53 act as susceptibility favoring factors. How human 
      leukocyte antigen (HLA)-mediated selection drives the evolution of HIV-1 and 
      which circulating variants are more likely to evade immune surveillance of the 
      population are now beginning to become clear. Importantly, the rare HLA alleles 
      in a population bear a selective advantage to the host because these can induce 
      immune responses against pre-adapted viruses. It is conceivable that previously 
      established protective HLA associations are shifting with the evolving cytotoxic 
      T lymphocyte (CTL) epitopes and may not remain protective in future. At the same 
      time, this process is unraveling novel sub-dominant epitopes of the virus which 
      could now be incorporated as the dominant target CTL epitopes. An insight into 
      the population-specific correlates of protection is hence necessary for designing 
      future anti-HIV therapeutic and/or prophylactic vaccine formulation(s).
FAU - Kaur, G
AU  - Kaur G
AD  - Department of Transplant Immunology and Immunogenetics, All India Institute of 
      Medical Sciences, Ansari Nagar, New Delhi, India. gurvinder@hotmail.com
FAU - Mehra, N
AU  - Mehra N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090918
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*etiology/genetics/immunology/transmission
MH  - Disease Progression
MH  - Genes, MHC Class II/*physiology
MH  - HIV Infections/complications/*genetics/*immunology/transmission
MH  - *HIV-1/immunology/physiology
MH  - Humans
MH  - Inflammation/genetics/immunology
MH  - Models, Biological
MH  - Polymorphism, Genetic/immunology/physiology
RF  - 50
EDAT- 2009/09/22 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - TAN1337 [pii]
AID - 10.1111/j.1399-0039.2009.01337.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2009 Nov;74(5):373-85. doi: 10.1111/j.1399-0039.2009.01337.x. 
      Epub 2009 Sep 18.