PMID- 19765641
OWN - NLM
STAT- MEDLINE
DCOM- 20100422
LR  - 20101118
IS  - 1879-3177 (Electronic)
IS  - 0887-2333 (Linking)
VI  - 24
IP  - 1
DP  - 2010 Feb
TI  - In vitro profiling of endocrine disrupting effects of phenols.
PG  - 201-7
LID - 10.1016/j.tiv.2009.09.008 [doi]
AB  - Some phenols have been suspected to modulate the endocrine systems of wildlife 
      and humans, but less is known about their interactions with different types of 
      nuclear receptors. In this study, the ability of 2-tert-butylphenol, 
      2-isopropylphenol, 4-tert-octylphenol (4-t-OP), 2,4-dichlorophenol (2,4-DCP), 
      3,4-dichlorophenol (3,4-DCP), pentachlorophenol (PCP), bisphenols A (BPA), 
      tetrabromobisphenol A (TBBPA), tetrachlorobisphenol A (TCBPA) and 4-phenylphenol 
      to activate estrogen receptor (ER), androgen receptor (AR), progesterone receptor 
      (PR) and estrogen-related receptor (ERR) were determined using a set of 
      recombined yeast strains. It was found that 4-t-OP, 3,4-DCP, PCP, BPA, TBBPA, 
      TCBPA and 4-phenylphenol were ERalpha agonists, while 4-t-OP, PCP and 
      4-phenylphenol showed ERalpha antagonistic activities. 2-tert-Butylphenol, 
      4-t-OP, 2-isopropylphenol, 2,4-DCP, 3,4-DCP, BPA, TCBPA and 4-phenylphenol were 
      antagonists for AR, whereas none of the compounds studied were found to be an AR 
      agonist. TCBPA, TBBPA and PCP were PR antagonists, and 2-tert-butylphenol, 
      3,4-DCP, 4-t-OP, 4-phenylphenol and 2-isopropylphenol were weak inhibitors on 
      expression under control of the PR. None of the phenols were PR agonists. 
      2-tert-Butylphenol, 4-t-OP and PCP were ERRgamma inverse agonists, while 2,4-DCP, 
      3,4-DCP, PCP, BPA, TBBPA and TCBPA exhibited the ability to reverse the ERR 
      inhibition induced by 4-hydroxytamoxifen. Based on the functional agonistic or 
      antagonistic receptor-mediated effects, we further discussed the possible action 
      mechanisms of these phenols as endocrine disrupting chemicals.
FAU - Li, Jian
AU  - Li J
AD  - State Key Laboratory of Environmental Aquatic Chemistry, Research Center for 
      Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
FAU - Ma, Mei
AU  - Ma M
FAU - Wang, Zijian
AU  - Wang Z
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090916
PL  - England
TA  - Toxicol In Vitro
JT  - Toxicology in vitro : an international journal published in association with 
      BIBRA
JID - 8712158
RN  - 0 (Androgen Receptor Antagonists)
RN  - 0 (Androgens)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Phenols)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Androgen Receptor Antagonists
MH  - Androgens
MH  - Animals
MH  - Endocrine Disruptors/chemistry/*toxicity
MH  - Female
MH  - Humans
MH  - Male
MH  - Phenols/chemistry/*toxicity
MH  - Receptors, Cytoplasmic and Nuclear/drug effects
MH  - Receptors, Estrogen/agonists/antagonists & inhibitors
MH  - Receptors, Progesterone/agonists/antagonists & inhibitors
MH  - Saccharomyces cerevisiae/drug effects/genetics
MH  - Structure-Activity Relationship
MH  - beta-Galactosidase/metabolism
EDAT- 2009/09/22 06:00
MHDA- 2010/04/23 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/04/03 00:00 [received]
PHST- 2009/08/07 00:00 [revised]
PHST- 2009/09/11 00:00 [accepted]
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/04/23 06:00 [medline]
AID - S0887-2333(09)00264-1 [pii]
AID - 10.1016/j.tiv.2009.09.008 [doi]
PST - ppublish
SO  - Toxicol In Vitro. 2010 Feb;24(1):201-7. doi: 10.1016/j.tiv.2009.09.008. Epub 2009 
      Sep 16.