PMID- 19766200
OWN - NLM
STAT- MEDLINE
DCOM- 20100621
LR  - 20181201
IS  - 1095-9564 (Electronic)
IS  - 1074-7427 (Linking)
VI  - 93
IP  - 2
DP  - 2010 Feb
TI  - Differential effects of MDMA and scopolamine on working versus reference memory 
      in the radial arm maze task.
PG  - 151-6
LID - 10.1016/j.nlm.2009.09.005 [doi]
AB  - Previous research has suggested that the disruption to memory-task performance 
      seen following acute exposure to 3,4-methylenedioxymethaphemtamine (MDMA) with 
      rats might best be characterized as reference memory impairment rather than a 
      working memory impairment. The current study specifically compared the effects of 
      MDMA and scopolamine on measures of working versus reference memory in an 
      eight-arm radial maze task. It was predicted that scopolamine would produce a 
      greater impairment with respect to the working memory component of the task, 
      whereas MDMA would produce a greater impairment to reference memory. On each 
      trial rats were allowed to make a total of four arm visits in order to collect 
      the reinforcers located at the end of different arms in the maze. Working memory 
      errors were indicated by re-visiting an already visited arm during a trial, 
      whereas visiting an arm that was never baited on any trial indicated a reference 
      memory error. Using a within subjects design, rats were exposed to a range of 
      doses of scopolamine and MDMA administered acutely. An interaction between drug 
      type and memory error type was found. Specifically, scopolamine produced more 
      working memory errors than reference memory errors, while MDMA produced the 
      opposite pattern of significantly more reference memory errors compared to 
      working memory error. This finding supported the hypothesis that MDMA disrupts 
      reference memory processes in terms of an impairment in the strategies or rules 
      used for solving memory tasks.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Kay, C
AU  - Kay C
AD  - School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 
      New Zealand.
FAU - Harper, D N
AU  - Harper DN
FAU - Hunt, M
AU  - Hunt M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090917
PL  - United States
TA  - Neurobiol Learn Mem
JT  - Neurobiology of learning and memory
JID - 9508166
RN  - 0 (Cholinergic Antagonists)
RN  - 0 (Serotonin Agents)
RN  - DL48G20X8X (Scopolamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Cholinergic Antagonists/administration & dosage/*pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Male
MH  - Maze Learning/*drug effects
MH  - Memory/*drug effects
MH  - Memory, Short-Term/drug effects
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Neuropsychological Tests
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Scopolamine/administration & dosage/*pharmacology
MH  - Serotonin Agents/administration & dosage/*pharmacology
MH  - Time Factors
EDAT- 2009/09/22 06:00
MHDA- 2010/06/22 06:00
CRDT- 2009/09/22 06:00
PHST- 2008/12/10 00:00 [received]
PHST- 2009/09/09 00:00 [revised]
PHST- 2009/09/12 00:00 [accepted]
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/06/22 06:00 [medline]
AID - S1074-7427(09)00195-6 [pii]
AID - 10.1016/j.nlm.2009.09.005 [doi]
PST - ppublish
SO  - Neurobiol Learn Mem. 2010 Feb;93(2):151-6. doi: 10.1016/j.nlm.2009.09.005. Epub 
      2009 Sep 17.