PMID- 19766472
OWN - NLM
STAT- MEDLINE
DCOM- 20100115
LR  - 20091013
IS  - 1879-0372 (Electronic)
IS  - 0952-7915 (Linking)
VI  - 21
IP  - 5
DP  - 2009 Oct
TI  - Immune reconstitution after haematopoietic stem cell transplantation: obstacles 
      and anticipated progress.
PG  - 544-8
LID - 10.1016/j.coi.2009.08.001 [doi]
AB  - Improvement of immune reconstitution after haematopoietic stem cell 
      transplantation (HSCT) is a key issue determining the clinical outcome of this 
      widely used therapeutic approach. To this end, new strategies have been prompted 
      by recent discoveries in immunology. In the setting of human leukocyte antigen 
      (HLA) geno(pheno)identical HSCT, better prevention and treatment of acute and 
      chronic graft-versus-host disease (GvHD) could significantly attenuate the thymic 
      epithelium damage responsible for delayed and incomplete T-cell reconstitution. 
      In a haploidentical setting, methods that would significantly accelerate 
      neothymopoiesis in the months following injection of highly purified CD34+ cells 
      are warranted. If these objectives could be achieved, the haploidentical 
      procedure would become more readily available to patients affected by acquired or 
      inherited disorders of the haematopoietic system.
FAU - Cavazzana-Calvo, Marina
AU  - Cavazzana-Calvo M
AD  - Assistance Publique Hopitaux de Paris (AP-HP), Department of Biotherapy, Hopital 
      Necker Enfants-Malades, Paris, France. m.cavazzana@nck.aphp.fr
FAU - Andre-Schmutz, Isabelle
AU  - Andre-Schmutz I
FAU - Dal Cortivo, Liliane
AU  - Dal Cortivo L
FAU - Neven, Benedicte
AU  - Neven B
FAU - Hacein-Bey-Abina, Salima
AU  - Hacein-Bey-Abina S
FAU - Fischer, Alain
AU  - Fischer A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090918
PL  - England
TA  - Curr Opin Immunol
JT  - Current opinion in immunology
JID - 8900118
RN  - 0 (Antigens, CD34)
SB  - IM
MH  - Adoptive Transfer
MH  - Antigens, CD34/immunology
MH  - Graft vs Host Disease/*immunology/prevention & control/therapy
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - T-Lymphocytes/cytology/*immunology/transplantation
MH  - Thymus Gland/cytology/immunology
MH  - Transplantation Immunology
RF  - 30
EDAT- 2009/09/22 06:00
MHDA- 2010/01/16 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/06/08 00:00 [received]
PHST- 2009/08/07 00:00 [revised]
PHST- 2009/08/07 00:00 [accepted]
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/01/16 06:00 [medline]
AID - S0952-7915(09)00170-8 [pii]
AID - 10.1016/j.coi.2009.08.001 [doi]
PST - ppublish
SO  - Curr Opin Immunol. 2009 Oct;21(5):544-8. doi: 10.1016/j.coi.2009.08.001. Epub 
      2009 Sep 18.