PMID- 19766691
OWN - NLM
STAT- MEDLINE
DCOM- 20100415
LR  - 20161125
IS  - 1873-6351 (Electronic)
IS  - 0278-6915 (Linking)
VI  - 48
IP  - 1
DP  - 2010 Jan
TI  - Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by 
      inhibiting ERK and NF-kappaB transcriptional activity.
PG  - 47-52
LID - 10.1016/j.fct.2009.09.013 [doi]
AB  - Monocyte chemoattractant protein-1 (MCP-1) is a potent mediator of macrophage 
      migration and therefore, plays an essential role in early events of inflammation. 
      In the present study, we show the protein kinase C activator, phorbol myristate 
      acetate (PMA), potently induced mRNA expression and secretion of the C-C 
      chemokine MCP-1 in U937 cells. We found that curcumin, a natural biologically 
      active compound extracted from rhizomes of Curcuma species, significantly 
      inhibited the PMA-induced increase in MCP-1 expression and secretion. These 
      effects of curcumin are dose dependent and correlate with the suppression of 
      MCP-1 mRNA expression levels. Curcumin inhibited PMA-mediated activation of 
      extracellular signal-regulated kinase (ERK) and NF-kappaB transcriptional 
      activity. Therefore, one possible anti-inflammatory mechanism of curcumin may be 
      to inhibit the secretions of inflammatory MCP-1 chemokine.
CI  - Copyright 2009 Elsevier Ltd. All rights reserved.
FAU - Lim, Jun Hee
AU  - Lim JH
AD  - Department of Immunology, School of Medicine, Keimyung University, 194 
      DongSan-Dong, Taegu 700-712, Republic of Korea.
FAU - Kwon, Taeg Kyu
AU  - Kwon TK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090918
PL  - England
TA  - Food Chem Toxicol
JT  - Food and chemical toxicology : an international journal published for the British 
      Industrial Biological Research Association
JID - 8207483
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Coloring Agents)
RN  - 0 (NF-kappa B)
RN  - 0 (Tetrazolium Salts)
RN  - 0 (Thiazoles)
RN  - 0 (Transcription Factor AP-1)
RN  - 63231-63-0 (RNA)
RN  - EC 1.13.12.- (Luciferases)
RN  - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
RN  - EUY85H477I (thiazolyl blue)
RN  - IT942ZTH98 (Curcumin)
RN  - NI40JAQ945 (Tetradecanoylphorbol Acetate)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Blotting, Western
MH  - Cell Nucleus/chemistry
MH  - Chemokine CCL2/*biosynthesis
MH  - Coloring Agents
MH  - Curcumin/*pharmacology
MH  - Electrophoretic Mobility Shift Assay
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Extracellular Signal-Regulated MAP Kinases/*antagonists & inhibitors
MH  - Humans
MH  - Luciferases/genetics
MH  - NF-kappa B/*antagonists & inhibitors
MH  - Promoter Regions, Genetic/genetics
MH  - RNA/biosynthesis/isolation & purification
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tetradecanoylphorbol Acetate/*antagonists & inhibitors/*toxicity
MH  - Tetrazolium Salts
MH  - Thiazoles
MH  - Transcription Factor AP-1/metabolism
MH  - Transcription, Genetic/drug effects
MH  - Transfection
MH  - U937 Cells
EDAT- 2009/09/22 06:00
MHDA- 2010/04/16 06:00
CRDT- 2009/09/22 06:00
PHST- 2009/08/10 00:00 [received]
PHST- 2009/09/07 00:00 [revised]
PHST- 2009/09/14 00:00 [accepted]
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2010/04/16 06:00 [medline]
AID - S0278-6915(09)00421-9 [pii]
AID - 10.1016/j.fct.2009.09.013 [doi]
PST - ppublish
SO  - Food Chem Toxicol. 2010 Jan;48(1):47-52. doi: 10.1016/j.fct.2009.09.013. Epub 
      2009 Sep 18.