PMID- 19768161
OWN - NLM
STAT- MEDLINE
DCOM- 20091229
LR  - 20240322
IS  - 0065-7778 (Print)
IS  - 0065-7778 (Linking)
VI  - 120
DP  - 2009
TI  - Toward a comprehensive understanding of allergic lung disease.
PG  - 33-48
AB  - Allergic asthma is a respiratory disease induced by exposure to environmental 
      agents that elicit allergic inflammation and transient airway obstruction and 
      which produce the characteristic symptoms of cough and dyspnea. Prior to the 
      advent of experimental models, asthma was believed to be caused primarily by the 
      degranulation of mast cells and eosinophils primed by antigen-specific 
      immunoglobulin E (IgE). More recent studies in mice have shown that T cells 
      primarily mediate antigen-dependent airway obstruction and allergic inflammation 
      through secretion of the cytokines interleukin 4 (IL- 4) and IL-13. Our 
      additional studies indicate that a major environmental link to asthma may be 
      through exposure to environmental proteinases and especially airway infection by 
      proteinase-producing organisms such as fungi. Pending verification in humans, 
      these findings suggest entirely new therapeutic interventions in asthma that 
      include the restricted use of anti-inflammatory therapy and universal application 
      of anti-fungal agents.
FAU - Corry, David B
AU  - Corry DB
AD  - Department of Medicine, One Baylor Plaza, BCM285, Baylor College of Medicine, 
      Houston, TX 77030, USA. dcorry@bcm.tmc.edu
FAU - Kheradmand, Farrah
AU  - Kheradmand F
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Trans Am Clin Climatol Assoc
JT  - Transactions of the American Clinical and Climatological Association
JID - 7507559
RN  - 0 (Allergens)
RN  - 0 (Antigens, Fungal)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.4.- (Peptide Hydrolases)
SB  - IM
MH  - Allergens
MH  - Animals
MH  - Antigens, Fungal
MH  - Aspergillus niger/enzymology/immunology/pathogenicity
MH  - Asthma/etiology/immunology/*physiopathology/therapy
MH  - Disease Models, Animal
MH  - Fungi/enzymology/immunology/pathogenicity
MH  - Humans
MH  - Immunoglobulin E/metabolism
MH  - Mice
MH  - Peptide Hydrolases/immunology
MH  - Th2 Cells/immunology
PMC - PMC2744551
COIS- Potential Conflicts of Interest: None disclosed.
EDAT- 2009/09/22 06:00
MHDA- 2009/12/30 06:00
PMCR- 2009/01/01
CRDT- 2009/09/22 06:00
PHST- 2009/09/22 06:00 [entrez]
PHST- 2009/09/22 06:00 [pubmed]
PHST- 2009/12/30 06:00 [medline]
PHST- 2009/01/01 00:00 [pmc-release]
PST - ppublish
SO  - Trans Am Clin Climatol Assoc. 2009;120:33-48.