PMID- 19769735
OWN - NLM
STAT- MEDLINE
DCOM- 20091023
LR  - 20201215
IS  - 1749-6632 (Electronic)
IS  - 0077-8923 (Linking)
VI  - 1174
DP  - 2009 Sep
TI  - Combining conventional therapies with intratumoral injection of autologous 
      dendritic cells and activated T cells to treat patients with advanced cancers.
PG  - 41-50
LID - 10.1111/j.1749-6632.2009.04934.x [doi]
AB  - Dendritic cells (DCs) are potent antigen-presenting cells that have been used in 
      cancer immunotherapy. To take advantage of the ability of DCs to acquire 
      antigenic materials from their environment and generate primary as well as recall 
      immune responses, 37 patients with advanced cancers were enrolled in a series of 
      protocols based on direct intratumoral injection of immature DCs. To augment 
      antigen uptake and antitumor immune response, DC injection was combined with 
      radiotherapy or chemotherapy and/or injection of activated T cells. Treatments 
      were well tolerated with no adverse reactions. Clinical responses were based on 
      Response Evaluation Criteria in Solid Tumors, with the majority of patients 
      showing stable disease. One of two patients who also received local radiation 
      achieved a sustained complete response at injected and metastatic sites. The 
      clinical responses observed in cancer patients with advanced disease suggest 
      potential effectiveness of combination strategies and establish the basis for the 
      current treatment protocol that is underway.
FAU - Mann, Dean L
AU  - Mann DL
AD  - Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 
      21201, USA. dmann001@umaryland.edu
FAU - Celluzzi, Christina M
AU  - Celluzzi CM
FAU - Hankey, Kim G
AU  - Hankey KG
FAU - Harris, Kristina M
AU  - Harris KM
FAU - Watanabe, Ryuko
AU  - Watanabe R
FAU - Hasumi, Kenichiro
AU  - Hasumi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (Antigens, CD)
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (HLA-DR Antigens)
SB  - IM
MH  - Antigen-Presenting Cells/immunology/transplantation
MH  - Antigens, CD/analysis
MH  - Breast Neoplasms/immunology
MH  - Colorectal Neoplasms/immunology
MH  - Combined Modality Therapy
MH  - Culture Media, Conditioned/pharmacology
MH  - Dendritic Cells/*immunology/transplantation
MH  - Female
MH  - HLA-DR Antigens/analysis/genetics
MH  - Humans
MH  - Lymphocyte Activation
MH  - Lymphocytes/immunology
MH  - Neoplasms/drug therapy/*immunology/radiotherapy
MH  - Stomach Neoplasms/immunology
MH  - T-Lymphocytes/*immunology/transplantation
MH  - Transplantation, Autologous
EDAT- 2009/09/23 06:00
MHDA- 2009/10/24 06:00
CRDT- 2009/09/23 06:00
PHST- 2009/09/23 06:00 [entrez]
PHST- 2009/09/23 06:00 [pubmed]
PHST- 2009/10/24 06:00 [medline]
AID - NYAS4934 [pii]
AID - 10.1111/j.1749-6632.2009.04934.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2009 Sep;1174:41-50. doi: 10.1111/j.1749-6632.2009.04934.x.