PMID- 19769950
OWN - NLM
STAT- MEDLINE
DCOM- 20100223
LR  - 20131121
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Linking)
VI  - 1302
DP  - 2009 Dec 11
TI  - MDMA (ecstasy) modulates locomotor and prefrontal cortex sensory evoked activity.
PG  - 175-82
LID - 10.1016/j.brainres.2009.09.048 [doi]
AB  - Ingestion of 3, 4-methylenedioxymethamphetamine (MDMA) leads to heightened 
      response to sensory stimulation; thus, MDMA is referred to as "ecstasy" because 
      it produces pleasurable enhancement of such sensation. There have been no 
      electrophysiological studies that report the consequences of MDMA on sensory 
      input. The present study was initiated to study the effects of acute and chronic 
      MDMA on locomotor activity and sensory evoked field potential from freely 
      behaving rats previously implanted with permanent electrodes in the prefrontal 
      cortex (PFC). The main findings of this study are that: (1) acute MDMA augments 
      locomotor behavior and attenuates the incoming sensory input, (2) chronic 
      treatment of MDMA elicits behavioral sensitization, (3) chronic administration of 
      MDMA results in attenuation of the baseline activity of the sensory evoked field 
      potential, and (4) administration of rechallenge MDMA result in enhancement of 
      the PFC sensory evoked field potential.
FAU - Atkins, Kristal
AU  - Atkins K
AD  - Department of Neurobiology and Anatomy, The University of Texas-Medical School at 
      Houston, Houston, TX 77225, USA.
FAU - Burks, Tilithia
AU  - Burks T
FAU - Swann, Alan C
AU  - Swann AC
FAU - Dafny, Nachum
AU  - Dafny N
LA  - eng
GR  - R01 DA027222/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090918
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Hallucinogens)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Auditory Perception/drug effects/physiology
MH  - Behavior, Animal/drug effects/physiology
MH  - Drug Administration Schedule
MH  - Electrodes, Implanted
MH  - Evoked Potentials/*drug effects/physiology
MH  - Evoked Potentials, Auditory/drug effects/physiology
MH  - Hallucinogens/pharmacology
MH  - Male
MH  - Motor Activity/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Perception/drug effects/physiology
MH  - Prefrontal Cortex/*drug effects/physiology
MH  - Rats
MH  - Rats, Inbred WKY
MH  - Sensation/*drug effects/physiology
MH  - Sensation Disorders/chemically induced/physiopathology
EDAT- 2009/09/23 06:00
MHDA- 2010/02/24 06:00
CRDT- 2009/09/23 06:00
PHST- 2009/06/29 00:00 [received]
PHST- 2009/09/02 00:00 [revised]
PHST- 2009/09/13 00:00 [accepted]
PHST- 2009/09/23 06:00 [entrez]
PHST- 2009/09/23 06:00 [pubmed]
PHST- 2010/02/24 06:00 [medline]
AID - S0006-8993(09)01979-9 [pii]
AID - 10.1016/j.brainres.2009.09.048 [doi]
PST - ppublish
SO  - Brain Res. 2009 Dec 11;1302:175-82. doi: 10.1016/j.brainres.2009.09.048. Epub 
      2009 Sep 18.