PMID- 19770630
OWN - NLM
STAT- MEDLINE
DCOM- 20100202
LR  - 20151119
IS  - 1533-0311 (Electronic)
IS  - 0193-1091 (Linking)
VI  - 31
IP  - 8
DP  - 2009 Dec
TI  - A dyshidrosis-like variant of adult T-cell leukemia/lymphoma with 
      clinicopathological aspects of mycosis fungoides. A case report.
PG  - 834-7
LID - 10.1097/DAD.0b013e3181ac04fe [doi]
AB  - Adult T-cell leukemia/lymphoma (ATL) is an aggressive type of leukemia/lymphoma 
      associated with the human T-cell lymphotropic virus (HTLV-I). We describe an 
      adult male patient clinically and pathologically diagnosed as mycosis fungoides 
      and treated with chemotherapy after which complete involution of the lesions 
      occurred. The disease relapsed with confluent dyshidrosis-like vesicles on the 
      palmoplantar regions, followed by disseminated vesiculopapules and associated 
      lymphocytosis. A serological test performed at this time revealed HTLV-I 
      infection, and a diagnosis of chronic ATL was made. Monoclonal integration of 
      HTLV-I was detected in peripheral blood mononuclear cells by inverse long 
      polymerase chain reaction. A skin biopsy revealed spongiosis, Pautrier abscesses, 
      and intraepidermal vesicles with atypical lymphocytes and an infiltration of 
      small and atypical CD4 lymphocytes in the superficial dermis. Proliferative index 
      (Ki-67) was 70%. This is the first reported vesicular cutaneous ATL with 
      confirmation of HTLV-I proviral integration. The delay that occurred in 
      diagnosing ATL was due to the fact that mycosis fungoides and ATL may present the 
      same clinical, histopathological, and immunohistochemical features.
FAU - Bittencourt, Achilea L
AU  - Bittencourt AL
AD  - Department of Pathology, Federal University of Bahia, Salvador, Bahia, Brazil.
FAU - Mota, Karla
AU  - Mota K
FAU - Oliveira, Rodrigo F
AU  - Oliveira RF
FAU - Farre, Lourdes
AU  - Farre L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Dermatopathol
JT  - The American Journal of dermatopathology
JID - 7911005
RN  - 0 (Interferon-alpha)
RN  - 4B9XT59T7S (Zidovudine)
RN  - 5J49Q6B70F (Vincristine)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - VB0R961HZT (Prednisone)
RN  - CHOP protocol
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Cyclophosphamide
MH  - Diabetes Mellitus
MH  - Diagnosis, Differential
MH  - Doxorubicin
MH  - Eczema, Dyshidrotic/*pathology/virology
MH  - HTLV-I Infections/complications/*pathology
MH  - Human T-lymphotropic virus 1
MH  - Humans
MH  - Immunohistochemistry
MH  - Interferon-alpha/therapeutic use
MH  - Leukemia-Lymphoma, Adult T-Cell/drug therapy/*pathology/virology
MH  - Male
MH  - Mycosis Fungoides/drug therapy/*pathology
MH  - Polymerase Chain Reaction
MH  - Prednisone
MH  - Skin Neoplasms/drug therapy/*pathology/virology
MH  - Vincristine
MH  - Zidovudine/therapeutic use
EDAT- 2009/09/23 06:00
MHDA- 2010/02/03 06:00
CRDT- 2009/09/23 06:00
PHST- 2009/09/23 06:00 [entrez]
PHST- 2009/09/23 06:00 [pubmed]
PHST- 2010/02/03 06:00 [medline]
AID - 10.1097/DAD.0b013e3181ac04fe [doi]
PST - ppublish
SO  - Am J Dermatopathol. 2009 Dec;31(8):834-7. doi: 10.1097/DAD.0b013e3181ac04fe.