PMID- 19771908
OWN - NLM
STAT- MEDLINE
DCOM- 20110609
LR  - 20120622
IS  - 2096-7993 (Print)
IS  - 2096-7993 (Linking)
VI  - 23
IP  - 12
DP  - 2009 Jun
TI  - [The expression of oncogene AKT2 in laryngeal squamous cell carcinoma and its 
      clinical significance].
PG  - 539-41, 545
AB  - OBJECTIVE: To investigate the expression and clinical significance of oncogene 
      AKT2 in laryngeal squamous cell carcinoma (LSCC). METHOD: The expression of AKT2 
      protein was measured with immunohistochemistry (Elivision two steps) in 60 cases 
      of LSCC tissue, 28 cases of peri-cancer tissue and 16 cases of normal laryngeal 
      epithelium, the relationship between AKT2 expression and clinical pathologic 
      factors in LSCC was also analyzed. RESULT: The positive rates of AKT2 protein 
      expression in LSCC and peri-cancer tissue were 56.7% (34/60), 14.3% (4/28) 
      respectively. There was no expression of AKT2 in normal laryngeal epithelium. The 
      positive rate of AKT2 protein expression in LSCC was significantly higher than 
      that in peri-cancer tissue and normal laryngeal epithelium (P < 0.05, 
      respectively). The positive rate of AKT2 was correlated with tumor site, lymph 
      node metastasis and clinical stage of LSCC (P < 0.05, respectively), but wasn't 
      correlated with patient's age, sex, and T stage (P > 0.05, respectively). 
      CONCLUSION: AKT2 might play an important role in the tumorigenesis and 
      development of LSCC, and it was suggested that AKT2 could be a useful marker for 
      predicting tumorigenesis, invasion and metastasis potential of LSCC.
FAU - Chen, Yingchao
AU  - Chen Y
AD  - Department of Otolaryngology Head and Neck Surgery, the Central Hospital of 
      Xiaogan, Xiaogan, 432100, China.
FAU - He, Yuanping
AU  - He Y
FAU - Zhang, Shaorong
AU  - Zhang S
FAU - Li, Lixiang
AU  - Li L
FAU - Zhu, Xinhua
AU  - Zhu X
FAU - Liu, Yuehui
AU  - Liu Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical 
      otorhinolaryngology, head, and neck surgery
JID - 101303164
RN  - EC 2.7.11.1 (AKT2 protein, human)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Laryngeal Mucosa/metabolism/pathology
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Proto-Oncogene Proteins c-akt/*metabolism
EDAT- 2009/09/24 06:00
MHDA- 2011/06/10 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2011/06/10 06:00 [medline]
PST - ppublish
SO  - Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Jun;23(12):539-41, 545.