PMID- 19772762
OWN - NLM
STAT- MEDLINE
DCOM- 20100513
LR  - 20161020
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 30
IP  - 4
DP  - 2009 Jul-Aug
TI  - Several interleukin-4 and interleukin-13 gene single nucleotide polymorphisms 
      among Chinese asthmatic patients.
PG  - 413-8
LID - 10.2500/aap.2009.30.3255 [doi]
AB  - Asthma is a common respiratory disease associated with airway hyperactivity and 
      high total serum immunoglobulin E (IgE) levels. The asthmatic phenotypes are 
      widely considered to be caused by environmental effects on genetically 
      predisposed individuals. Interleukin (IL)-4 and IL-13 act on B cells and regulate 
      the IgE production, and the single nucleotide polymorphisms (SNPs) in the IL-4 
      and IL-13 genes are implicated in the pathogenesis of asthma. To study the 
      association of IL-4 and IL-13 gene polymorphisms with asthma, we sequenced the 
      promoter regions and exons of IL-4 and IL-13 genes in two groups: one (spouses 
      group) consisted of 13 pairs of asthmatic patients (cases) and their unaffected 
      spouses (controls); the other (parents group) consisted of 11 pairs of asthmatic 
      children (cases) and their unaffected father/mother (controls). In total, seven 
      polymorphisms were identified, one novel and six previously reported. However, 
      according to the results of the statistical analysis we performed, no 
      statistically significant association of these SNPs and asthma was observed (p > 
      0.05). Asthma is largely determined by the accumulation of several certain 
      genetic variations other than one or two SNPs. Future function studies may be 
      able to help us reveal the significance of genetic variants we identified in this 
      study.
FAU - Jiang, Peng
AU  - Jiang P
AD  - Anhui Geriatric Institute, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, Anhui, China.
FAU - Liu, Ji
AU  - Liu J
FAU - Yan, Xue-Bo
AU  - Yan XB
FAU - Liu, Rong-Yu
AU  - Liu RY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Interleukin-13)
RN  - 207137-56-2 (Interleukin-4)
SB  - IM
MH  - Asthma/*genetics
MH  - China
MH  - DNA Mutational Analysis
MH  - Exons/genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-13/*genetics/immunology
MH  - Interleukin-4/*genetics/immunology
MH  - Male
MH  - Parents
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic
MH  - Respiratory Function Tests
MH  - Spouses
EDAT- 2009/09/24 06:00
MHDA- 2010/05/14 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2010/05/14 06:00 [medline]
AID - 10.2500/aap.2009.30.3255 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2009 Jul-Aug;30(4):413-8. doi: 10.2500/aap.2009.30.3255.