PMID- 19772900
OWN - NLM
STAT- MEDLINE
DCOM- 20100506
LR  - 20220409
IS  - 1873-2747 (Electronic)
IS  - 0361-9230 (Linking)
VI  - 81
IP  - 4-5
DP  - 2010 Mar 16
TI  - Effects of beta-carboline harmine on behavioral and physiological parameters 
      observed in the chronic mild stress model: further evidence of antidepressant 
      properties.
PG  - 491-6
LID - 10.1016/j.brainresbull.2009.09.008 [doi]
AB  - The chronic mild stress (CMS) model has been used as an animal model of 
      depression which induces anhedonic behavior in rodents. The present study was 
      aimed to evaluate the behavioral and physiological effects of administration of 
      beta-carboline harmine in rats exposed to CMS procedure. To this aim, after 40 
      days of exposure to CMS procedure, rats were treated with harmine (15 mg/kg/day) 
      for 7 days. In this study, sweet food consumption, adrenal gland weight, 
      adrenocorticotrophin hormone (ACTH) levels, and hippocampal 
      brain-derived-neurotrophic factor (BDNF) protein levels were assessed. Our 
      findings demonstrated that chronic stressful situations induced anhedonia, 
      hypertrophy of adrenal gland weight, increase ACTH circulating levels in rats and 
      increase BDNF protein levels. Interestingly, treatment with harmine reversed 
      anhedonia, the increase of adrenal gland weight, normalized ACTH circulating 
      levels and BDNF protein levels. Finally, these findings further support the 
      hypothesis that harmine could be a new pharmacological tool for the treatment of 
      depression.
CI  - Copyright 2009 Elsevier Inc. All rights reserved.
FAU - Fortunato, Jucelia J
AU  - Fortunato JJ
AD  - Laboratorio de Neurociencias and Instituto Nacional de Ciencia e Tecnologia 
      Translacional em Medicina, Programa de Pos-Graduacao em Ciencias da Saude, 
      Unidade Academica de Ciencias da Saude, Universidade do Extremo Sul Catarinense, 
      88806-000 Criciuma, SC, Brazil.
FAU - Reus, Gislaine Z
AU  - Reus GZ
FAU - Kirsch, Tamires R
AU  - Kirsch TR
FAU - Stringari, Roberto B
AU  - Stringari RB
FAU - Fries, Gabriel R
AU  - Fries GR
FAU - Kapczinski, Flavio
AU  - Kapczinski F
FAU - Hallak, Jaime E
AU  - Hallak JE
FAU - Zuardi, Antonio W
AU  - Zuardi AW
FAU - Crippa, Jose A
AU  - Crippa JA
FAU - Quevedo, Joao
AU  - Quevedo J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090920
PL  - United States
TA  - Brain Res Bull
JT  - Brain research bulletin
JID - 7605818
RN  - 0 (Antidepressive Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbolines)
RN  - 4FHH5G48T7 (Harmine)
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Adrenocorticotropic Hormone/blood
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Carbolines/*pharmacology
MH  - Chronic Disease
MH  - Diet
MH  - Disease Models, Animal
MH  - Feeding Behavior/drug effects
MH  - Harmine/*pharmacology
MH  - Hippocampus/drug effects/metabolism
MH  - Male
MH  - Neuropsychological Tests
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Psychological/blood/*drug therapy/*metabolism
MH  - Treatment Outcome
EDAT- 2009/09/24 06:00
MHDA- 2010/05/07 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/09/05 00:00 [received]
PHST- 2009/09/14 00:00 [revised]
PHST- 2009/09/15 00:00 [accepted]
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2010/05/07 06:00 [medline]
AID - S0361-9230(09)00304-9 [pii]
AID - 10.1016/j.brainresbull.2009.09.008 [doi]
PST - ppublish
SO  - Brain Res Bull. 2010 Mar 16;81(4-5):491-6. doi: 
      10.1016/j.brainresbull.2009.09.008. Epub 2009 Sep 20.