PMID- 19774380
OWN - NLM
STAT- MEDLINE
DCOM- 20101028
LR  - 20221207
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 30
IP  - 10
DP  - 2010 Aug
TI  - High frequencies of HLA-B27 in Chinese patients with suspected of ankylosing 
      spondylitis.
PG  - 1305-9
LID - 10.1007/s00296-009-1148-4 [doi]
AB  - This study was performed to investigate the frequency of human leukocyte antigen 
      (HLA)-B27 in Chinese patients with suspected of ankylosing spondylitis (AS) and 
      to assess the clinical significance of HLA-B27 typing. A total of 1,016 patients 
      suspected of AS were classified into six groups based on one major AS-related 
      clinical manifestation. HLA-B27 was determined by polymerase chain reaction using 
      sequence-specific primers. The frequency of B27 ranged between 24.3 and 46.7% 
      among the patient groups, significantly higher than in healthy controls (2.4%). 
      In the same group, the frequency of B27 in young (< or = 40 years) and in male 
      patients was significantly higher than in the old and in female (P < 0.01). 
      During a 1-year follow-up, 102 subjects were definitely diagnosed as AS, but only 
      one B27(-) patient. Of the 102 definite patients, 69 (67.6%) definite patients 
      were distributed in group 1 (low back pain and stiffness) with the higher 
      incidence (28.5%) of AS. The incidence of AS in the same group was found with a 
      similar pattern to the frequency of B27, in male and young patients significantly 
      greater, except groups 4 and 6 (peripheral arthritis and alteration of skin). 
      These findings confirm that HLA-B27 is one of sensitive diagnostic tools for 
      early AS and suggest that there was a remarkable clinical significance of HLA-B27 
      typing in Chinese patients suspected of AS, particularly a young man who presents 
      with low back pain and stiffness for > 3 months.
FAU - Liu, Xiang
AU  - Liu X
AD  - Clinical Laboratory Medicine Department, Union Hospital, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, China.
FAU - Li, Yi-Rong
AU  - Li YR
FAU - Hu, Li-Hua
AU  - Hu LH
FAU - Zhou, Zhi-Ming
AU  - Zhou ZM
FAU - Chen, Feng-Hua
AU  - Chen FH
FAU - Ning, Yong
AU  - Ning Y
FAU - Yao, Qun-Feng
AU  - Yao QF
LA  - eng
PT  - Journal Article
DEP - 20090923
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (HLA-B27 Antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Asian People/ethnology
MH  - Child
MH  - China/epidemiology
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - HLA-B27 Antigen/*genetics
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Genetic/*genetics
MH  - Spondylitis, Ankylosing/ethnology/*genetics/pathology
MH  - Young Adult
EDAT- 2009/09/24 06:00
MHDA- 2010/10/29 06:00
CRDT- 2009/09/24 06:00
PHST- 2009/07/15 00:00 [received]
PHST- 2009/09/13 00:00 [accepted]
PHST- 2009/09/24 06:00 [entrez]
PHST- 2009/09/24 06:00 [pubmed]
PHST- 2010/10/29 06:00 [medline]
AID - 10.1007/s00296-009-1148-4 [doi]
PST - ppublish
SO  - Rheumatol Int. 2010 Aug;30(10):1305-9. doi: 10.1007/s00296-009-1148-4. Epub 2009 
      Sep 23.