PMID- 19775214
OWN - NLM
STAT- MEDLINE
DCOM- 20091222
LR  - 20090924
IS  - 1557-8682 (Electronic)
IS  - 1527-0297 (Linking)
VI  - 10
IP  - 3
DP  - 2009 Fall
TI  - Changes of cardiac structure and function in pediatric patients with high 
      altitude pulmonary hypertension in Tibet.
PG  - 247-52
LID - 10.1089/ham.2009.0001 [doi]
AB  - This study was performed to evaluate the structural and functional cardiac 
      changes in pediatric high altitude pulmonary hypertension (HAPH) using magnetic 
      resonance imaging (MRI) and Doppler echocardiography (Echo). Ten patients with 
      infantile HAPH (aged 12 to 24 months) and eight healthy age-matched children 
      (control group) underwent MRI and Echo studies. All participants were born and 
      living in the Qinghai-Tibetan Plateau (3600 to 4600 m). The studies were 
      performed at the Children's Hospital located in Xining, Qinghai (2260 m). The 
      right and left ventricular end-systolic (RVEST and LVEST, respectively) and 
      end-diastolic (RVEDT and LVEDT, respectively) wall thicknesses were calculated 
      directly from the MRI scans. The mean pulmonary arterial pressure (mPAP) was 
      measured using Echo. RVEST was significantly higher in the HAPH group than in the 
      control group (6.8 +/- 0.6 and 3.7 +/- 0.5 mm, respectively; p < 0.001). RVEDT 
      was significantly higher in the HAPH patients when compared with the control 
      group (4.9 +/- 1.1 and 2.1 +/- 0.3 mm, respectively; p < 0.05). Mean PAP in the 
      HAPH group was significantly higher than in the control group (66.8 +/- 6.7 and 
      33.8 +/- 3.6 mmHg, respectively; p < 0.001) and was positively correlated with 
      RVEDT (r(2) = 0.562, p < 0.001). Right ventricular ejection fraction was 
      significantly lower in the HAPH group when compared with the control group (29.8 
      +/- 11.8 and 55.5 +/- 9.9%, respectively; p < 0.001); however, left ventricular 
      ejection fraction was similar in both groups. These results indicate that 
      hypoxia-induced infantile HAPH leads to right ventricular hypertrophy in these 
      patients. These structural cardiac changes may lead to right ventricular 
      dysfunction and right heart failure; however, left ventricular function is 
      preserved.
FAU - Ge, Ri-Li
AU  - Ge RL
AD  - Research Center for High Altitude Medicine, Qinghai University, Xining, Qinghai, 
      P.R. China. geriligao@hotmail.com
FAU - Ma, Ru-yan
AU  - Ma RY
FAU - Bao, Hai-hua
AU  - Bao HH
FAU - Zhao, Xi-peng
AU  - Zhao XP
FAU - Qi, Hai-ning
AU  - Qi HN
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - High Alt Med Biol
JT  - High altitude medicine & biology
JID - 100901183
SB  - IM
MH  - *Altitude
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Diastole/physiology
MH  - Echocardiography, Doppler
MH  - Female
MH  - Heart Ventricles/*pathology
MH  - Humans
MH  - Hypertension, Pulmonary/*physiopathology
MH  - Infant
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Stroke Volume/physiology
MH  - Systole/physiology
MH  - Tibet
MH  - Ventricular Dysfunction, Right/pathology/physiopathology
EDAT- 2009/09/25 06:00
MHDA- 2009/12/23 06:00
CRDT- 2009/09/25 06:00
PHST- 2009/09/25 06:00 [entrez]
PHST- 2009/09/25 06:00 [pubmed]
PHST- 2009/12/23 06:00 [medline]
AID - 10.1089/ham.2009.0001 [doi]
PST - ppublish
SO  - High Alt Med Biol. 2009 Fall;10(3):247-52. doi: 10.1089/ham.2009.0001.