PMID- 19775292
OWN - NLM
STAT- MEDLINE
DCOM- 20110104
LR  - 20211020
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Print)
IS  - 1015-6305 (Linking)
VI  - 20
IP  - 3
DP  - 2010 May
TI  - Axonal pathology and loss precede demyelination and accompany chronic lesions in 
      a spontaneously occurring animal model of multiple sclerosis.
PG  - 551-9
LID - 10.1111/j.1750-3639.2009.00332.x [doi]
AB  - Axonal damage has been highlighted recently as a cause of neurological disability 
      in various demyelinating diseases, including multiple sclerosis, either as a 
      primary pathological change or secondary due to myelin loss. To characterize and 
      quantify axonal damage and loss in canine distemper demyelinating 
      leukoencephalomyelitis (DL), formalin-fixed paraffin-embedded cerebella were 
      investigated histochemically and immunohistochemically using the modified 
      Bielschowsky's silver stain as well as antibodies against nonphosphorylated 
      (n-NF), phosphorylated neurofilament (p-NF) and beta-amyloid precursor protein 
      (beta-APP). Injured axons characterized by immunoreactivity against n-NF and 
      beta-APP were detected in early distemper lesions without demyelination. In 
      subacute and chronic demyelinating lesions the number of injured axons increased. 
      Moreover, a significant decrease in axonal density was observed within lesions 
      and in the normal appearing white matter in DL as determined by morphometric 
      analyses using Bielschowsky's silver stain and p-NF immunohistochemistry. 
      Summarized, the observed findings indicate that axonal damage (i) occurs early in 
      DL; (ii) can be detected before myelin loss; and (iii) represents a pivotal 
      feature in advanced lesions. It must be postulated that axonal damage plays an 
      important role in the initial phase as a primary event and during progression of 
      nervous distemper as a result of demyelination.
FAU - Seehusen, Frauke
AU  - Seehusen F
AD  - Department of Pathology, University of Veterinary Medicine, Hannover, Germany.
FAU - Baumgartner, Wolfgang
AU  - Baumgartner W
LA  - eng
PT  - Journal Article
DEP - 20090826
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
SB  - IM
MH  - Animals
MH  - Axons/*pathology
MH  - Brain/*pathology
MH  - Chronic Disease
MH  - Disease Models, Animal
MH  - Distemper/*pathology
MH  - Dogs
MH  - Leukoencephalopathies/*pathology
MH  - Multiple Sclerosis/*pathology
MH  - Nerve Fibers, Myelinated/*pathology
MH  - Wallerian Degeneration/etiology/*pathology
PMC - PMC8094816
EDAT- 2009/09/25 06:00
MHDA- 2011/01/05 06:00
PMCR- 2009/08/26
CRDT- 2009/09/25 06:00
PHST- 2009/09/25 06:00 [entrez]
PHST- 2009/09/25 06:00 [pubmed]
PHST- 2011/01/05 06:00 [medline]
PHST- 2009/08/26 00:00 [pmc-release]
AID - BPA332 [pii]
AID - 10.1111/j.1750-3639.2009.00332.x [doi]
PST - ppublish
SO  - Brain Pathol. 2010 May;20(3):551-9. doi: 10.1111/j.1750-3639.2009.00332.x. Epub 
      2009 Aug 26.