PMID- 19777396 OWN - NLM STAT- MEDLINE DCOM- 20100122 LR - 20090924 IS - 2040-3429 (Electronic) IS - 1472-4472 (Linking) VI - 10 IP - 10 DP - 2009 Oct TI - Bariatric surgery: what is the effect on type 2 diabetes? PG - 1078-84 AB - Type 2 diabetes mellitus (T2DM) is a costly chronic disease that is associated with increased morbidity and mortality. Despite the development of numerous pharmacological agents, diet and exercise programs, and behavior-modification protocols, bariatric surgery remains the most effective tool for the durable reversal of T2DM. This review discusses the known effects of bariatric surgery on T2DM, with a particular focus on Roux-en-Y gastric bypass. FAU - Dar, Moahad AU - Dar M AD - Department of Surgery, East Carolina University, Brody School of Medicine, Greenville, NC 27834, USA. FAU - Pories, Walter J AU - Pories WJ LA - eng PT - Journal Article PT - Review PL - England TA - Curr Opin Investig Drugs JT - Current opinion in investigational drugs (London, England : 2000) JID - 100965718 SB - IM MH - Animals MH - Bariatric Surgery/*methods MH - Diabetes Mellitus, Type 2/etiology/physiopathology/*surgery MH - Gastric Bypass/methods MH - Humans MH - Insulin Resistance MH - Insulin-Secreting Cells/metabolism MH - Obesity/complications/*surgery RF - 67 EDAT- 2009/09/25 06:00 MHDA- 2010/01/23 06:00 CRDT- 2009/09/25 06:00 PHST- 2009/09/25 06:00 [entrez] PHST- 2009/09/25 06:00 [pubmed] PHST- 2010/01/23 06:00 [medline] PST - ppublish SO - Curr Opin Investig Drugs. 2009 Oct;10(10):1078-84.