PMID- 19778329
OWN - NLM
STAT- MEDLINE
DCOM- 20100818
LR  - 20131121
IS  - 1600-0765 (Electronic)
IS  - 0022-3484 (Linking)
VI  - 45
IP  - 1
DP  - 2010 Feb
TI  - Matrix metalloproteinase-3 gene polymorphism in renal transplant patients with 
      gingival overgrowth.
PG  - 143-7
LID - 10.1111/j.1600-0765.2009.01221.x [doi]
AB  - BACKGROUND AND OBJECTIVE: Gingival enlargement frequently occurs in transplant 
      patients receiving immunosuppressive drugs. It was hypothesized that gingival 
      enlargement associated with cyclosporine use results from reduced degradation of 
      extracellular matrix in the gingiva. Matrix metalloproteinase-3 (MMP-3) is 
      involved in biodegradation of the extracellular matrix, and its inhibition may 
      contribute to an abnormal accumulation of fibronectin and proteoglycans, which 
      are MMP-3 substrates. The aim of this study was to investigate whether an 
      association exists between MMP-3 genotypes and gingival enlargement in kidney 
      transplant patients medicated with cyclosporine A. MATERIAL AND METHODS: 
      Sixty-four unrelated kidney transplant patients suffering from gingival 
      overgrowth, as well as 111 control transplant patients without gingival 
      overgrowth, were enrolled in the study. Gingival overgrowth was assessed 6 mo 
      after transplantation. During the post-transplant period all patients were given 
      cyclosporine A as a principal immunosuppressive agent. MMP-3 polymorphism was 
      determined using a PCR restriction fragment length polymorphism assay. RESULTS: 
      In kidney transplant patients suffering from gingival overgrowth the mean 
      gingival overgrowth score was 1.35 +/- 0.57, whereas in control subjects the mean 
      gingival overgrowth score was 0.0. The distribution of MMP-3-1178A/dupA alleles 
      among all kidney transplant patients, as well as in the two study subgroups, did 
      not differ significantly from Hardy-Weinberg equilibrium. The frequency of the 
      MMP-3-1171A/A genotype (28.1% for gingival overgrowth vs. 26.1% for controls) and 
      of the MMP-3-1171dupA/dupA genotype (32.8% for gingival overgrowth vs. 22.5% for 
      controls) was similar for both study groups. The risk of gingival overgrowth was 
      lowest among patients carrying the MMP-3-1171A/dupA genotype (odds ratio 0.52), 
      but this did not differ markedly from the other genotypes. CONCLUSION: No 
      association between MMP-3 gene polymorphism and gingival overgrowth was revealed 
      in kidney transplant patients administered cyclosporine A.
FAU - Drozdzik, A
AU  - Drozdzik A
AD  - Department of Periodontology, Pomeranian Medical University, Szczecin, Poland. 
      drozdzik@sci.pam.szczecin.pl
FAU - Kurzawski, M
AU  - Kurzawski M
FAU - Lener, A
AU  - Lener A
FAU - Kozak, M
AU  - Kozak M
FAU - Banach, J
AU  - Banach J
FAU - Drozdzik, M
AU  - Drozdzik M
LA  - eng
PT  - Journal Article
DEP - 20090923
PL  - United States
TA  - J Periodontal Res
JT  - Journal of periodontal research
JID - 0055107
RN  - 0 (Immunosuppressive Agents)
RN  - 83HN0GTJ6D (Cyclosporine)
RN  - EC 3.4.24.17 (MMP3 protein, human)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - JAC85A2161 (Adenine)
SB  - IM
MH  - Adenine
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Cyclosporine/adverse effects
MH  - Female
MH  - Follow-Up Studies
MH  - Gene Frequency
MH  - Genotype
MH  - Gingival Overgrowth/enzymology/*etiology
MH  - Humans
MH  - Immunosuppressive Agents/adverse effects
MH  - *Kidney Transplantation
MH  - Male
MH  - Matrix Metalloproteinase 3/*genetics
MH  - Middle Aged
MH  - Polymerase Chain Reaction
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Promoter Regions, Genetic/genetics
MH  - Young Adult
EDAT- 2009/09/26 06:00
MHDA- 2010/08/19 06:00
CRDT- 2009/09/26 06:00
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2010/08/19 06:00 [medline]
AID - JRE1221 [pii]
AID - 10.1111/j.1600-0765.2009.01221.x [doi]
PST - ppublish
SO  - J Periodontal Res. 2010 Feb;45(1):143-7. doi: 10.1111/j.1600-0765.2009.01221.x. 
      Epub 2009 Sep 23.