PMID- 19778818
OWN - NLM
STAT- MEDLINE
DCOM- 20110404
LR  - 20090925
IS  - 1673-4254 (Print)
IS  - 1673-4254 (Linking)
VI  - 29
IP  - 9
DP  - 2009 Sep
TI  - [Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic 
      rabbits].
PG  - 1887-9
AB  - OBJECTIVE: To study the effects of Tongxinluo on the expressions of matrix 
      metalloproteinase-3 (MMP-3), MMP-9 and peroxisome proliferators-activated 
      receptor gamma (PPARgamma) in atherosclerotic rabbits and explore the mechanism 
      of its anti-atherosclerotic effect. METHODS: Twenty-four rabbits were randomized 
      equally into control group, atherosclerotic model group (fed with high-fat diet 
      for 14 weeks) and Tongxinluo group. The expressions of MMP-3, 9 and PPARgamma in 
      the 3 groups were observed by means of immunohistochemistry. RESULTS: The 
      expressions of MMP-3, 9 and PPARgamma in the model group and Tongxinluo group 
      were significantly higher than those in the control group (P<0.01). After 
      high-fat diet feeding for 14 weeks, Tongxinluo group showed significantly lower 
      expressions of MMP-3 and 9 but higher expression of PPARgamma than the model 
      group (P<0.01). CONCLUSION: Tongxinluo can inhibit the expression of MMP-3 and 9 
      and increase the expression of PPARgamma, which might be the mechanism of its 
      anti-atherosclerotic effect.
FAU - Cao, Hong-yan
AU  - Cao HY
AD  - Department of Cardiology, First Huspital, Jilin University, Changchun, China.
FAU - Qin, Ling
AU  - Qin L
FAU - Huang, Ke-xin
AU  - Huang KX
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Nan Fang Yi Ke Da Xue Xue Bao
JT  - Nan fang yi ke da xue xue bao = Journal of Southern Medical University
JID - 101266132
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (PPAR gamma)
RN  - 0 (tongxinluo)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
SB  - IM
MH  - Animals
MH  - Atherosclerosis/*metabolism
MH  - Drugs, Chinese Herbal/*pharmacology
MH  - Male
MH  - Matrix Metalloproteinase 3/genetics/*metabolism
MH  - Matrix Metalloproteinase 9/genetics/*metabolism
MH  - PPAR gamma/genetics/*metabolism
MH  - Rabbits
MH  - Random Allocation
EDAT- 2009/09/26 06:00
MHDA- 2011/04/05 06:00
CRDT- 2009/09/26 06:00
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2011/04/05 06:00 [medline]
PST - ppublish
SO  - Nan Fang Yi Ke Da Xue Xue Bao. 2009 Sep;29(9):1887-9.