PMID- 19779896
OWN - NLM
STAT- MEDLINE
DCOM- 20100920
LR  - 20211020
IS  - 1860-2002 (Electronic)
IS  - 1536-1632 (Print)
IS  - 1536-1632 (Linking)
VI  - 12
IP  - 3
DP  - 2010 Jun
TI  - Development and validation of a Monte Carlo simulation tool for multi-pinhole 
      SPECT.
PG  - 295-304
LID - 10.1007/s11307-009-0263-7 [doi]
AB  - PURPOSE: In this work, we developed and validated a Monte Carlo simulation (MCS) 
      tool for investigation and evaluation of multi-pinhole (MPH) SPECT imaging. 
      PROCEDURES: This tool was based on a combination of the SimSET and MCNP codes. 
      Photon attenuation and scatter in the object, as well as penetration and scatter 
      through the collimator detector, are modeled in this tool. It allows accurate and 
      efficient simulation of MPH SPECT with focused pinhole apertures and 
      user-specified photon energy, aperture material, and imaging geometry. The MCS 
      method was validated by comparing the point response function (PRF), detection 
      efficiency (DE), and image profiles obtained from point sources and phantom 
      experiments. A prototype single-pinhole collimator and focused four- and 
      five-pinhole collimators fitted on a small animal imager were used for the 
      experimental validations. We have also compared computational speed among various 
      simulation tools for MPH SPECT, including SimSET-MCNP, MCNP, SimSET-GATE, and 
      GATE for simulating projections of a hot sphere phantom. RESULTS: We found good 
      agreement between the MCS and experimental results for PRF, DE, and image 
      profiles, indicating the validity of the simulation method. The relative 
      computational speeds for SimSET-MCNP, MCNP, SimSET-GATE, and GATE are 1: 2.73: 
      3.54: 7.34, respectively, for 120-view simulations. We also demonstrated the 
      application of this MCS tool in small animal imaging by generating a set of 
      low-noise MPH projection data of a 3D digital mouse whole body phantom. 
      CONCLUSIONS: The new method is useful for studying MPH collimator designs, data 
      acquisition protocols, image reconstructions, and compensation techniques. It 
      also has great potential to be applied for modeling the collimator-detector 
      response with penetration and scatter effects for MPH in the quantitative 
      reconstruction method.
FAU - Mok, Greta S P
AU  - Mok GS
AD  - Department of Diagnostic Radiology and Organ Imaging, The Chinese University of 
      Hong Kong, Shatin, N.T., Hong Kong. gretamok@cuhk.edu.hk
FAU - Du, Yong
AU  - Du Y
FAU - Wang, Yuchuan
AU  - Wang Y
FAU - Frey, Eric C
AU  - Frey EC
FAU - Tsui, Benjamin M W
AU  - Tsui BM
LA  - eng
GR  - R01 EB001558/EB/NIBIB NIH HHS/United States
GR  - R01 EB001558-01A2/EB/NIBIB NIH HHS/United States
GR  - EB001558/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Validation Study
DEP - 20090925
PL  - United States
TA  - Mol Imaging Biol
JT  - Molecular imaging and biology
JID - 101125610
RN  - 7440-26-8 (Technetium)
SB  - IM
MH  - Animals
MH  - *Computer Simulation
MH  - Mice
MH  - *Monte Carlo Method
MH  - Phantoms, Imaging
MH  - Reproducibility of Results
MH  - Technetium
MH  - Time Factors
MH  - Tomography, Emission-Computed, Single-Photon/*instrumentation/*methods
PMC - PMC3086288
MID - NIHMS286669
EDAT- 2009/09/26 06:00
MHDA- 2010/09/21 06:00
PMCR- 2011/05/03
CRDT- 2009/09/26 06:00
PHST- 2008/12/08 00:00 [received]
PHST- 2009/05/04 00:00 [accepted]
PHST- 2009/02/15 00:00 [revised]
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2010/09/21 06:00 [medline]
PHST- 2011/05/03 00:00 [pmc-release]
AID - 10.1007/s11307-009-0263-7 [doi]
PST - ppublish
SO  - Mol Imaging Biol. 2010 Jun;12(3):295-304. doi: 10.1007/s11307-009-0263-7. Epub 
      2009 Sep 25.