PMID- 19780184
OWN - NLM
STAT- MEDLINE
DCOM- 20100121
LR  - 20131121
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 30
IP  - 5
DP  - 2009 Nov
TI  - Quantitative assessment of myocardial T2 relaxation times in cardiac amyloidosis.
PG  - 942-6
LID - 10.1002/jmri.21918 [doi]
AB  - PURPOSE: To evaluate cardiac MRI (CMR) in the diagnosis of cardiac amyloidosis by 
      comparing the T2 relaxation times of left ventricular myocardium in a pilot 
      patient group to a normal range established in healthy controls. MATERIALS AND 
      METHODS: Forty-nine patients with suspected amyloidosis-related cardiomyopathy 
      underwent comprehensive CMR examination, which included assessment of myocardial 
      T2 relaxation times, ventricular function, resting myocardial perfusion, and late 
      gadolinium enhancement (LGE) imaging. T2-weighted basal, mid, and apical left 
      ventricular slices were acquired in each patient using a multislice T2 
      magnetization preparation spiral sequence. Slice averaged T2 relaxation times 
      were subsequently calculated offline and compared to the previously established 
      normal range. RESULTS: Twelve of the 49 patients were confirmed to have cardiac 
      amyloidosis by biopsy. There was no difference in mean T2 relaxation times 
      between the amyloid cases and normal controls (51.3 +/- 8.1 vs. 52.1 +/- 3.1 
      msec, P = 0.63). Eleven of the 12 amyloid patients had abnormal findings by CMR, 
      eight having LGE involving either ventricles or atria and four demonstrating 
      resting subendocardial perfusion defects. CONCLUSION: CMR is a potentially 
      valuable tool in the diagnosis of cardiac amyloidosis. However, calculation of 
      myocardial T2 relaxation times does not appear useful in distinguishing areas of 
      amyloid deposition from normal myocardium.
FAU - Sparrow, Patrick
AU  - Sparrow P
AD  - Division of Cardiothoracic Imaging, Department of Medical Imaging, University 
      Health Network and Mount Sinai Hospital, Toronto, Canada. 
      patsparrow@doctors.net.uk
FAU - Amirabadi, Afsaneh
AU  - Amirabadi A
FAU - Sussman, Marshall S
AU  - Sussman MS
FAU - Paul, Narinder
AU  - Paul N
FAU - Merchant, Naeem
AU  - Merchant N
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - AU0V1LM3JT (Gadolinium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/*pathology
MH  - Biopsy
MH  - Case-Control Studies
MH  - Female
MH  - Gadolinium/pharmacology
MH  - Heart Diseases/*pathology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Perfusion
MH  - Pilot Projects
MH  - Reference Values
EDAT- 2009/09/26 06:00
MHDA- 2010/01/22 06:00
CRDT- 2009/09/26 06:00
PHST- 2009/09/26 06:00 [entrez]
PHST- 2009/09/26 06:00 [pubmed]
PHST- 2010/01/22 06:00 [medline]
AID - 10.1002/jmri.21918 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2009 Nov;30(5):942-6. doi: 10.1002/jmri.21918.