PMID- 19781512
OWN - NLM
STAT- MEDLINE
DCOM- 20091222
LR  - 20191111
IS  - 1873-4480 (Electronic)
IS  - 1873-4480 (Linking)
VI  - 9
IP  - 3
DP  - 2009
TI  - Clinical importance of identifying immunoglobulin E-mediated disease in patients 
      with asthma.
PG  - 20-9
AB  - The strong association between allergy and asthma is well documented; however, 
      few practitioners-even asthma specialists-accurately estimate the percentage of 
      patients with asthma who have clinically relevant allergies. Because allergen 
      exposure can prompt airway inflammation, trigger asthma exacerbations, and 
      possibly lead to negative health outcomes for patients with asthma, identifying 
      allergies and immunoglobulin E (IgE)-mediated disease in patients with persistent 
      asthma is crucial. Updated Expert Panel 3 asthma guidelines from the National 
      Asthma Education and Prevention Program reinforce the need for clinicians to 
      identify allergic sensitivities in patients with persistent asthma and determine 
      their clinical relevance. Allergy testing can be useful in educating the patient 
      with IgE-mediated asthma about the need for allergic trigger avoidance and can 
      help determine optimal therapy for patients with concomitant asthma and allergy. 
      Implementing this guideline recommendation, however, requires active clinical 
      engagement. Data from a recent observational study indicate that there may be a 
      substantial gap between guideline recommendations and actual clinical practice. 
      These data also suggest that when clinicians participate in education about the 
      role of IgE in asthma and begin testing their patients for allergy, the 
      recognition of allergies among patients with asthma dramatically increases.
FAU - Casale, Thomas B
AU  - Casale TB
AD  - Allergy/Immunology, Creighton University, Omaha, Nebraska, USA. 
      tbcasale@creighton.edu
FAU - Martin, Richard J
AU  - Martin RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Clin Cornerstone
JT  - Clinical cornerstone
JID - 9816002
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/complications/*immunology
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Hypersensitivity, Immediate/complications/*diagnosis/immunology
MH  - Immunoglobulin E/*blood
MH  - Practice Guidelines as Topic
MH  - Radioallergosorbent Test
MH  - Risk Factors
MH  - Skin Tests
EDAT- 2009/09/29 06:00
MHDA- 2009/12/23 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2009/12/23 06:00 [medline]
AID - S1098-3597(09)80009-4 [pii]
AID - 10.1016/s1098-3597(09)80009-4 [doi]
PST - ppublish
SO  - Clin Cornerstone. 2009;9(3):20-9. doi: 10.1016/s1098-3597(09)80009-4.