PMID- 19781803
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 86
IP  - 3
DP  - 2009 Dec
TI  - MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients 
      with type 2 diabetes.
PG  - 193-8
LID - 10.1016/j.diabres.2009.09.001 [doi]
AB  - AIMS: Cardiovascular diseases are the major cause of mortality in patients with 
      diabetes mellitus. Monocyte chemoattractant protein-1 (MCP-1) is a potent 
      chemokine and plays an important role in cardiovascular diseases. The objective 
      of this study was to evaluate the relation between the genotypes of the MCP-1 
      A-2518G polymorphism and the development of carotid atherosclerosis in patients 
      with type 2 diabetes. METHODS: The subjects were 303 unrelated patients who were 
      diagnosed with type 2 diabetes mellitus. To evaluate macroangiopathy, we measured 
      carotid artery intima-media thickness (IMT) by ultrasonography. The MCP-1 A-2518G 
      polymorphism was determined by TaqMan PCR method. RESULTS: IMT in patients with 
      the MCP-1 -2518 AG or GG genotype was significantly greater than the AA-genotype 
      (P=0.007). Simple regression analysis showed that age, systolic blood pressure, 
      LDL-cholesterol, the MCP-1 -2518 AG+GG polymorphism, and HbA1c level were 
      correlated with IMT (P<0.0001, <0.0001, 0.006, 0.007, 0.025, respectively). In 
      multiple regression analysis, the MCP-1 -2518 AG+GG polymorphism was the third 
      strongest independent determinant of IMT in patients with type 2 diabetes 
      (P=0.021), subsequent to age and systolic blood pressure. CONCLUSION: Assessment 
      of the MCP-1 A-2518G polymorphism would be useful in identifying the risk of 
      developing carotid atherosclerosis in patients with type 2 diabetes.
FAU - Yuasa, Sachiko
AU  - Yuasa S
AD  - Division of Metabolism, Department of Internal Medicine, Keio University School 
      of Medicine, Shinjuku-ku, Tokyo, Japan. sachicom@mvj.biglobe.ne.jp
FAU - Maruyama, Taro
AU  - Maruyama T
FAU - Yamamoto, Yukihiro
AU  - Yamamoto Y
FAU - Hirose, Hiroshi
AU  - Hirose H
FAU - Kawai, Toshihide
AU  - Kawai T
FAU - Matsunaga-Irie, Seiko
AU  - Matsunaga-Irie S
FAU - Itoh, Hiroshi
AU  - Itoh H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090924
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - JAC85A2161 (Adenine)
RN  - QR26YLT7LT (Thymine)
SB  - IM
MH  - Adenine
MH  - Aged
MH  - Asian People/genetics
MH  - Carotid Artery Diseases/complications/diagnostic imaging/*genetics
MH  - Chemokine CCL2/*genetics
MH  - Diabetes Mellitus, Type 2/*complications/genetics
MH  - Diabetic Angiopathies/diagnostic imaging/*genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Japan
MH  - Male
MH  - Polymerase Chain Reaction/methods
MH  - *Polymorphism, Genetic
MH  - *Polymorphism, Single Nucleotide
MH  - Regression Analysis
MH  - Thymine
MH  - Ultrasonography
EDAT- 2009/09/29 06:00
MHDA- 2010/02/02 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/01/03 00:00 [received]
PHST- 2009/08/19 00:00 [revised]
PHST- 2009/09/01 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
AID - S0168-8227(09)00372-6 [pii]
AID - 10.1016/j.diabres.2009.09.001 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2009 Dec;86(3):193-8. doi: 
      10.1016/j.diabres.2009.09.001. Epub 2009 Sep 24.