PMID- 19782253
OWN - NLM
STAT- MEDLINE
DCOM- 20110216
LR  - 20221207
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 54
IP  - 2
DP  - 2009 Oct
TI  - Clinical evidence for Japanese population based on prospective studies--linking 
      clinical trials and clinical practice.
PG  - 171-82
LID - 10.1016/j.jjcc.2009.05.001 [doi]
AB  - "Evidence-based medicine (EBM)" implies effective and high quality practice for 
      patients based on well-grounded medical science. The success of clinical trials 
      in Japan is essential to build original evidence specific for Japanese patients. 
      Based on this concept, we have performed several large-scale clinical trials to 
      provide EBM, including the Japanese Antiplatelets Myocardial Infarction Study 
      [JAMIS; clinical improvement in acute myocardial infarction (AMI) patients with 
      antiplatelet therapy], the Japanese beta-Blockers and Calcium Antagonists 
      Myocardial Infarction (JBCMI; comparison of the effects of beta-blockers and 
      calcium antagonists on cardiovascular events in post-AMI patients), a multicenter 
      study for aggressive lipid-lowering strategy by HMG-CoA reductase inhibitors in 
      patients with AMI (MUSASHI; effects of statin therapy on cardiovascular events in 
      patients with AMI), and the Japanese Primary Prevention of Atherosclerosis with 
      Aspirin for Diabetes (JPAD trial; efficacy of low-dose aspirin therapy for 
      primary prevention of atherosclerotic events in type 2 diabetic patients). The 
      results of these prospective studies were directly linked with clinical practice. 
      We have acquired the know-how of large-scale clinical trials; an important point 
      is to have passion for "buildup evidence specific for the Japanese" and to 
      recruit subjects for enrollment after explaining the significance of "clinical 
      trials for the Japanese".
FAU - Ogawa, Hisao
AU  - Ogawa H
AD  - Department of Cardiovascular Medicine, Graduate School of Medical Sciences, 
      Kumamoto University, 1-1-1 Honjo, Kumamoto City 860-8556, Japan. 
      ogawah@kumamoto-u.ac.jp
FAU - Kojima, Sunao
AU  - Kojima S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20090612
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
RN  - 0 (Adrenergic beta-Antagonists)
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - EYG5Y6355E (Trapidil)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Adrenergic beta-Antagonists/administration & dosage
MH  - Aged
MH  - Asian People
MH  - Aspirin/administration & dosage
MH  - Atherosclerosis/epidemiology/prevention & control
MH  - Calcium Channel Blockers/administration & dosage
MH  - Diabetes Complications
MH  - *Evidence-Based Medicine
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage
MH  - Incidence
MH  - Japan/epidemiology
MH  - Male
MH  - Multicenter Studies as Topic
MH  - Myocardial Infarction/*prevention & control
MH  - Platelet Aggregation Inhibitors/administration & dosage
MH  - Practice Guidelines as Topic
MH  - Prospective Studies
MH  - *Randomized Controlled Trials as Topic
MH  - Trapidil/administration & dosage
EDAT- 2009/09/29 06:00
MHDA- 2011/02/17 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/05/04 00:00 [received]
PHST- 2009/05/07 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2011/02/17 06:00 [medline]
AID - S0914-5087(09)00158-0 [pii]
AID - 10.1016/j.jjcc.2009.05.001 [doi]
PST - ppublish
SO  - J Cardiol. 2009 Oct;54(2):171-82. doi: 10.1016/j.jjcc.2009.05.001. Epub 2009 Jun 
      12.