PMID- 19782423
OWN - NLM
STAT- MEDLINE
DCOM- 20100201
LR  - 20221207
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Print)
IS  - 0168-8227 (Linking)
VI  - 86
IP  - 3
DP  - 2009 Dec
TI  - Variation in the perilipin gene (PLIN) affects glucose and lipid metabolism in 
      non-Hispanic white women with and without polycystic ovary syndrome.
PG  - 186-92
LID - 10.1016/j.diabres.2009.09.002 [doi]
AB  - Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in 
      women. It is characterized by chronic anovulation, hyperandrogenism, obesity and 
      a predisposition to type 2 diabetes mellitus (T2DM). Since obesity plays an 
      important role in the etiology of PCOS, we sought to determine if variants in the 
      perilipin gene (PLIN), a gene previously implicated in the development of 
      obesity, were also associated with PCOS. We typed six single nucleotide 
      polymorphisms (haplotype tagging and/or previously associated with obesity or 
      related metabolic traits) in PLIN in 305 unrelated non-Hispanic white women (185 
      with PCOS and 120 without PCOS). None of the variants was associated with PCOS 
      (P<0.05). However, the variant rs1052700*A was associated with increased risk for 
      glucose intolerance (impaired glucose tolerance or T2DM) in both non-PCOS 
      (OR=1.75 [1.02-3.01], P=0.044) and PCOS subjects (OR=1.67 [1.08-2.59], P=0.022). 
      It was also associated with increased LDL (P=0.007) and total cholesterol levels 
      (P=0.042). These results suggest that genetic variation in PLIN may affect 
      glucose and lipid metabolism in women both with and without PCOS.
FAU - Kawai, Toshihide
AU  - Kawai T
AD  - Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. 
      tkawai@sc.itc.keio.ac.jp
FAU - Ng, Maggie C Y
AU  - Ng MC
FAU - Hayes, M Geoffrey
AU  - Hayes MG
FAU - Yoshiuchi, Issei
AU  - Yoshiuchi I
FAU - Tsuchiya, Takafumi
AU  - Tsuchiya T
FAU - Robertson, Heather
AU  - Robertson H
FAU - Cox, Nancy J
AU  - Cox NJ
FAU - Polonsky, Kenneth S
AU  - Polonsky KS
FAU - Bell, Graeme I
AU  - Bell GI
FAU - Ehrmann, David A
AU  - Ehrmann DA
LA  - eng
GR  - R37 DK031842/DK/NIDDK NIH HHS/United States
GR  - DK-31842/DK/NIDDK NIH HHS/United States
GR  - DK-20579/DK/NIDDK NIH HHS/United States
GR  - R01 DK047486/DK/NIDDK NIH HHS/United States
GR  - R01 DK055889/DK/NIDDK NIH HHS/United States
GR  - M01 RR000055/RR/NCRR NIH HHS/United States
GR  - P60 DK020579/DK/NIDDK NIH HHS/United States
GR  - P30 DK020579/DK/NIDDK NIH HHS/United States
GR  - R37 DK031842-21/DK/NIDDK NIH HHS/United States
GR  - R01 DK047486-07/DK/NIDDK NIH HHS/United States
GR  - P30 DK020595/DK/NIDDK NIH HHS/United States
GR  - P60 DK020595/DK/NIDDK NIH HHS/United States
GR  - P60 DK020595-288763/DK/NIDDK NIH HHS/United States
GR  - RR-24992/RR/NCRR NIH HHS/United States
GR  - DK-20595/DK/NIDDK NIH HHS/United States
GR  - DK-47486/DK/NIDDK NIH HHS/United States
GR  - RR-00055/RR/NCRR NIH HHS/United States
GR  - UL1 RR024992/RR/NCRR NIH HHS/United States
GR  - DK-55889/DK/NIDDK NIH HHS/United States
GR  - M01 RR000055-466652/RR/NCRR NIH HHS/United States
GR  - UL1 RR024992-01/RR/NCRR NIH HHS/United States
GR  - R01 DK031842/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090925
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
RN  - 0 (Carrier Proteins)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
RN  - 0 (Perilipin-1)
RN  - 0 (Phosphoproteins)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Body Mass Index
MH  - Carrier Proteins
MH  - Diabetes Mellitus, Type 2/genetics
MH  - Female
MH  - *Genetic Variation
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Insulin/blood
MH  - Lipids/blood/*physiology
MH  - Perilipin-1
MH  - Phosphoproteins/*genetics
MH  - Polycystic Ovary Syndrome/blood/*genetics
MH  - White People/*genetics
PMC - PMC2794304
MID - NIHMS161294
EDAT- 2009/09/29 06:00
MHDA- 2010/02/02 06:00
PMCR- 2010/12/01
CRDT- 2009/09/29 06:00
PHST- 2009/07/11 00:00 [received]
PHST- 2009/08/30 00:00 [revised]
PHST- 2009/09/03 00:00 [accepted]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/02/02 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - S0168-8227(09)00373-8 [pii]
AID - 10.1016/j.diabres.2009.09.002 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2009 Dec;86(3):186-92. doi: 
      10.1016/j.diabres.2009.09.002. Epub 2009 Sep 25.