PMID- 1978271
OWN - NLM
STAT- MEDLINE
DCOM- 19901207
LR  - 20220310
IS  - 0161-813X (Print)
IS  - 0161-813X (Linking)
VI  - 11
IP  - 2
DP  - 1990 Summer
TI  - Neurochemical basis of neurotoxicity.
PG  - 317-21
AB  - The neurotoxic properties of 6-hydroxydopamine and 5,7-dihydroxytryptamine are 
      reviewed. The neurochemical responses of the dopaminergic and serotonergic 
      systems after methamphetamine (METH) are reported. METH decreased activities of 
      tyrosine hydroxylase and tryptophan hydroxylase; concentrations of dopamine (DA) 
      and 5-hydroxytryptamine (5HT) and their respective metabolites were decreased in 
      parallel with the decline in activity of the enzymes. When a variety of 
      pharmacologic or surgical procedures were used to decrease DA content prior to 
      administration of METH, the effects of METH were attenuated. From these data it 
      is inferred that DA is essential for the METH-induced response. 
      3,4-Methylenedioxymethamphetamine (MDMA) produced similar effects which were also 
      DA-dependent. Evidence for a role of glutamate and oxidative stress in the 
      neurotoxicity of the amphetamines is presented.
FAU - Gibb, J W
AU  - Gibb JW
AD  - Department of Pharmacology and Toxicology, University of Utah, Salt Lake City 
      84112.
FAU - Johnson, M
AU  - Johnson M
FAU - Hanson, G R
AU  - Hanson GR
LA  - eng
GR  - DA 00869/DA/NIDA NIH HHS/United States
GR  - DA 04222/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Neurotoxicology
JT  - Neurotoxicology
JID - 7905589
RN  - 0 (Biogenic Monoamines)
RN  - 0 (Designer Drugs)
RN  - 0 (Glutamates)
RN  - 333DO1RDJY (Serotonin)
RN  - 44RAL3456C (Methamphetamine)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/analogs & derivatives/toxicity
MH  - Animals
MH  - Biogenic Monoamines/metabolism
MH  - Designer Drugs/toxicity
MH  - Dopamine/metabolism
MH  - Glutamates/physiology
MH  - Methamphetamine/toxicity
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Nervous System/drug effects/*metabolism
MH  - Nervous System Diseases/*chemically induced
MH  - Serotonin/metabolism
EDAT- 1990/01/01 00:00
MHDA- 1990/01/01 00:01
CRDT- 1990/01/01 00:00
PHST- 1990/01/01 00:00 [pubmed]
PHST- 1990/01/01 00:01 [medline]
PHST- 1990/01/01 00:00 [entrez]
PST - ppublish
SO  - Neurotoxicology. 1990 Summer;11(2):317-21.