PMID- 19783867
OWN - NLM
STAT- MEDLINE
DCOM- 20100128
LR  - 20190911
IS  - 1347-8648 (Electronic)
IS  - 1347-8613 (Linking)
VI  - 111
IP  - 2
DP  - 2009 Oct
TI  - Methamphetamine- and 3,4-methylenedioxymethamphetamine-induced behavioral changes 
      in histamine H3-receptor knockout mice.
PG  - 167-74
AB  - Histamine H(3) receptors inhibit the release of not only histamine itself, but 
      also other neurotransmitters including dopamine. Previous papers have reported 
      that histaminergic neurons inhibit psychostimulant-induced behavioral changes. To 
      examine whether deficiency in histamine H(3) receptors influences 
      psychostimulant-induced behavioral sensitization and reward, we examined 
      locomotor activity, conditioned place preference (CPP), and c-Fos expression in 
      histamine H(3) receptor-gene knockout mice (H3KO) and their wild-type (WT) 
      counterparts before and after treatment with methamphetamine (METH) and 
      3,4-methylenedioxymethamphetamine (MDMA). The increase in locomotion induced by 
      treatment with METH or MDMA was lower in histamine H3KO mice than in WT mice, 
      while the locomotor sensitization was developed by METH or MDMA in both strains. 
      However, no significant difference in METH- and MDMA-induced preference scores of 
      CPP between histamine H3KO mice and WT mice was observed. Following treatment 
      with METH, the number of c-Fos-positive neurons in the the caudate-putamen of 
      histamine H3KO mice was lower than that in the caudate-putamen of WT mice. In 
      contrast, there was no significant difference in the number of the 
      psychostimulant-induced c-Fos-positive cells in the nucleus accumbens between the 
      two strains of mice. These findings suggest that deficiency in histamine H(3) 
      receptors may have inhibitory effects on psychostimulant-induced increase in 
      locomotion, but insignificant effects on the reward.
FAU - Okuda, Tomohiro
AU  - Okuda T
AD  - Department of Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
FAU - Zhang, Dongying
AU  - Zhang D
FAU - Shao, He
AU  - Shao H
FAU - Okamura, Nobuyuki
AU  - Okamura N
FAU - Takino, Naoko
AU  - Takino N
FAU - Iwamura, Tatsunori
AU  - Iwamura T
FAU - Sakurai, Eiko
AU  - Sakurai E
FAU - Yoshikawa, Takeo
AU  - Yoshikawa T
FAU - Yanai, Kazuhiko
AU  - Yanai K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090926
PL  - Japan
TA  - J Pharmacol Sci
JT  - Journal of pharmacological sciences
JID - 101167001
RN  - 0 (Receptors, Histamine H3)
RN  - 44RAL3456C (Methamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Behavior, Animal/*drug effects
MH  - Crosses, Genetic
MH  - Heterozygote
MH  - Male
MH  - Methamphetamine/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Motor Activity/drug effects
MH  - Mutation
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Receptors, Histamine H3/*genetics/*metabolism
MH  - Spatial Behavior/drug effects
EDAT- 2009/09/29 06:00
MHDA- 2010/01/29 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2010/01/29 06:00 [medline]
AID - JST.JSTAGE/jphs/09024FP [pii]
AID - 10.1254/jphs.09024fp [doi]
PST - ppublish
SO  - J Pharmacol Sci. 2009 Oct;111(2):167-74. doi: 10.1254/jphs.09024fp. Epub 2009 Sep 
      26.