PMID- 19784583
OWN - NLM
STAT- MEDLINE
DCOM- 20091015
LR  - 20131121
IS  - 0253-6269 (Print)
IS  - 0253-6269 (Linking)
VI  - 32
IP  - 9
DP  - 2009 Sep
TI  - Apoptosis induction effects of EGCG in laryngeal squamous cell carcinoma cells 
      through telomerase repression.
PG  - 1263-9
LID - 10.1007/s12272-009-1912-8 [doi]
AB  - Epigallocatechin-3-gallate (EGCG), the major component of green tea polyphenol, 
      has potent efficiency to prevent the growth of a variety of cancer cells. As a 
      novel anticancer agent for treatment of cancers, EGCG is promising and the 
      mechanism has not been fully understood. Laryngeal squamous cell carcinoma (LSCC) 
      is one common tumor in head and neck cancers. In the present study, we assess the 
      effects of EGCG on LSCC cell line Hep-2, and their possible involvement in 
      EGCG-induced apoptosis. The result showed that treatment of Hep-2 cells with EGCG 
      decreased the cell viability, inhibited the growth and proliferation, induced 
      apoptosis and increased the activity of caspase-3 in a dose-dependent manner. 
      Furthermore, we found that EGCG-treatment repressed telomerase activity 
      effectively in a concentration-dependent manner. The combined results show that 
      EGCG induced apoptosis in Hep-2 cells via inhibiting the telomerase activity.
FAU - Wang, Xi
AU  - Wang X
AD  - Research Center, Tangdu Hospital, Fourth Military Medical University, Xi'an, 
      China.
FAU - Hao, Miao-Wang
AU  - Hao MW
FAU - Dong, Ke
AU  - Dong K
FAU - Lin, Fang
AU  - Lin F
FAU - Ren, Ji-Hong
AU  - Ren JH
FAU - Zhang, Hui-Zhong
AU  - Zhang HZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090926
PL  - Korea (South)
TA  - Arch Pharm Res
JT  - Archives of pharmacal research
JID - 8000036
RN  - 0 (Antineoplastic Agents)
RN  - 8R1V1STN48 (Catechin)
RN  - BQM438CTEL (epigallocatechin gallate)
RN  - EC 2.7.7.49 (TERT protein, human)
RN  - EC 2.7.7.49 (Telomerase)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Antineoplastic Agents/*pharmacology
MH  - Apoptosis/*drug effects
MH  - Caspase 3/metabolism
MH  - Catechin/*analogs & derivatives/pharmacology
MH  - Cell Line, Tumor
MH  - Cell Proliferation/drug effects
MH  - Enzyme Activation/drug effects
MH  - G1 Phase/drug effects
MH  - Humans
MH  - Laryngeal Neoplasms/*drug therapy/pathology
MH  - Telomerase/*antagonists & inhibitors/genetics
EDAT- 2009/09/29 06:00
MHDA- 2009/10/16 06:00
CRDT- 2009/09/29 06:00
PHST- 2009/04/23 00:00 [received]
PHST- 2009/08/04 00:00 [accepted]
PHST- 2009/08/03 00:00 [revised]
PHST- 2009/09/29 06:00 [entrez]
PHST- 2009/09/29 06:00 [pubmed]
PHST- 2009/10/16 06:00 [medline]
AID - 10.1007/s12272-009-1912-8 [doi]
PST - ppublish
SO  - Arch Pharm Res. 2009 Sep;32(9):1263-9. doi: 10.1007/s12272-009-1912-8. Epub 2009 
      Sep 26.