PMID- 19786073
OWN - NLM
STAT- MEDLINE
DCOM- 20100114
LR  - 20220310
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 466
IP  - 3
DP  - 2009 Dec 11
TI  - State-dependent decrease in levels of brain-derived neurotrophic factor in 
      bipolar disorder: a meta-analytic study.
PG  - 139-43
LID - 10.1016/j.neulet.2009.09.044 [doi]
AB  - Evidence has suggested a role of brain-derived neurotrophic factor (BDNF) in the 
      pathogenesis of bipolar disorder (BD). Recent studies have examined BDNF levels 
      in BD patients, but showed inconsistent results. In current study, meta-analyses 
      by random-effects model were performed to compare blood BDNF levels between BD 
      patients and healthy controls, and examine patients based on different affective 
      status (manic, depressed, or euthymic state). Fifteen studies from 10 citations 
      were included into the analysis. Pooling of results from all studies indicated 
      that, overall, patients with BD had a lower level of BDNF than healthy controls 
      (p=1x10(-4)). But when separating these studies based on different affective 
      status, it showed that the significance existed only when comparing patients in 
      manic (p=0.0008) or depressed (p=0.02) state with controls, but not in euthymic 
      state (p=0.25). In addition, BDNF level was significantly increased after 
      pharmacological treatment of manic state (p=0.01). These findings indicate that 
      BDNF levels are abnormally reduced in manic and depressed states of BD, and the 
      reduced level in manic state increases after treatment. They suggest a role of 
      blood BDNF level as a state-dependent biomarker of bipolar disorder.
FAU - Lin, Pao-Yen
AU  - Lin PY
AD  - Department of Psychiatry, Chang Gung Memorial Hospital-Kaohsiung Medical Center, 
      Chang Gung University College of Medicine, 123 Ta-Pei Road, Niao-Sung Hsiang, 
      Kaohsiung County 833, Taiwan. py1029@adm.cgmh.org.tw
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20090926
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Bipolar Disorder/*blood/drug therapy/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Humans
EDAT- 2009/09/30 06:00
MHDA- 2010/01/15 06:00
CRDT- 2009/09/30 06:00
PHST- 2009/07/31 00:00 [received]
PHST- 2009/09/10 00:00 [revised]
PHST- 2009/09/23 00:00 [accepted]
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2010/01/15 06:00 [medline]
AID - S0304-3940(09)01272-5 [pii]
AID - 10.1016/j.neulet.2009.09.044 [doi]
PST - ppublish
SO  - Neurosci Lett. 2009 Dec 11;466(3):139-43. doi: 10.1016/j.neulet.2009.09.044. Epub 
      2009 Sep 26.