PMID- 19786084
OWN - NLM
STAT- MEDLINE
DCOM- 20100421
LR  - 20131121
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 127
IP  - 1
DP  - 2010 Jan 8
TI  - Anti-inflammatory and anti-asthmatic effects of Viola mandshurica W. Becker (VM) 
      ethanolic (EtOH) extract on airway inflammation in a mouse model of allergic 
      asthma.
PG  - 159-64
LID - 10.1016/j.jep.2009.09.033 [doi]
AB  - AIM OF THE STUDY: We investigated the efficacy of Viola mandshurica W. Becker 
      (VM) ethanolic (EtOH) extract in the treatment of bronchial asthma in an 
      ovalbumin (OVA)-induced asthmatic BALB/c mouse model. MATERIALS AND METHODS: 
      Female BALB/c mice were sensitized with intraperitoneal (i.p.) ovalbumin (OVA) on 
      days 0 and 14, and were next given intranasal OVA on days 28-30. Randomized 
      treatment groups of sensitized mice received VM EtOH extract, dexamethasone, or 
      placebo, orally, from days 28 to 30. RESULTS: VM EtOH extract significantly 
      inhibited increases in total immunoglobulin E (IgE) and cytokines IL-4 and IL-13 
      levels in serum and bronchoalveolar lavage fluid (BALF), and also effectively 
      suppressed airway hyperresponsiveness (AHR), eosinophilia, and mucus 
      hypersecretion, in mice with OVA-induced asthma. CONCLUSIONS: The results suggest 
      that VM EtOH extract and allied extracts could be useful herbal medicines for 
      asthma treatment, and that VM may also be a valuable lead material for 
      anti-asthma drug development.
CI  - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
FAU - Lee, Mee-Young
AU  - Lee MY
AD  - Immune Modulator Research Center, Korea Research Institute of Bioscience and 
      Biotechnology, PO Box 115, Yusung, Daejeon 305-600, Republic of Korea.
FAU - Yuk, Ji-Eun
AU  - Yuk JE
FAU - Kwon, Ok-Kyoung
AU  - Kwon OK
FAU - Kim, Hui-Seong
AU  - Kim HS
FAU - Oh, Sei-Ryang
AU  - Oh SR
FAU - Lee, Hyeong-Kyu
AU  - Lee HK
FAU - Ahn, Kyung-Seop
AU  - Ahn KS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090925
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Anti-Asthmatic Agents)
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Interleukins)
RN  - 0 (Plant Extracts)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3K9958V90M (Ethanol)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Anti-Asthmatic Agents/*therapeutic use
MH  - Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
MH  - Asthma/*drug therapy/immunology/physiopathology
MH  - Bronchi/*drug effects/pathology
MH  - Bronchial Hyperreactivity/immunology
MH  - Bronchoalveolar Lavage Fluid/chemistry
MH  - Eosinophilia/immunology
MH  - Ethanol/chemistry
MH  - Female
MH  - Hypersensitivity, Delayed/blood/chemically induced/*drug therapy
MH  - Immunoglobulin E/analysis/blood
MH  - Inflammation/drug therapy/immunology
MH  - Interleukins/analysis/blood
MH  - Korea
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mucus/drug effects
MH  - Ovalbumin/immunology/toxicity
MH  - Phytotherapy
MH  - Plant Extracts/*therapeutic use
MH  - Plants, Medicinal
MH  - Random Allocation
MH  - Viola/*chemistry
EDAT- 2009/09/30 06:00
MHDA- 2010/04/22 06:00
CRDT- 2009/09/30 06:00
PHST- 2009/03/12 00:00 [received]
PHST- 2009/09/17 00:00 [revised]
PHST- 2009/09/17 00:00 [accepted]
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2010/04/22 06:00 [medline]
AID - S0378-8741(09)00593-5 [pii]
AID - 10.1016/j.jep.2009.09.033 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2010 Jan 8;127(1):159-64. doi: 10.1016/j.jep.2009.09.033. Epub 
      2009 Sep 25.