PMID- 19786258
OWN - NLM
STAT- MEDLINE
DCOM- 20100602
LR  - 20211020
IS  - 1532-8414 (Electronic)
IS  - 1071-9164 (Linking)
VI  - 15
IP  - 8
DP  - 2009 Oct
TI  - A multicenter study of noninvasive cardiac output by bioreactance during 
      symptom-limited exercise.
PG  - 689-99
LID - 10.1016/j.cardfail.2009.04.005 [doi]
AB  - BACKGROUND: Hemodynamic responses to exercise were assessed in patients with 
      varying degrees of chronic heart failure (CHF) to determine the feasibility of 
      using bioreactance during exercise testing in multicenter studies of CHF. METHODS 
      AND RESULTS: A total of 210 symptomatic CHF patients and 22 subjects without 
      heart failure were subjected to symptom-limited exercise testing on a bicycle 
      (105) or treadmill (127) while measuring gas exchange for VO(2), cardiac output 
      (CO) noninvasively by a bioreactance technique, heart rate, and blood pressure. 
      Peak CO (pCO) and VO(2) (pVO(2)) during exercise were lower in patients with 
      higher New York Heart Association (NYHA) class, in females and in older patients. 
      Multiple linear regression analysis showed that pCO (L/min)=19.6+4.M 
      -2.1.NYHA+1.9.G -0.09.Age, where M=1 for treadmill and 0 for bicycle and G=1 for 
      males and 0 for females. Similarly, pVO(2) (mL/kg/min)=24+2.1.M -2.9.NYHA+1.26.G 
      -0.08.Age. VO(2) and CO were also highly correlated to each other: pCO 
      (mL/kg/min)=0.059+0.007.pVO(2)+0.036.M -0.025.G. Similar correlations were 
      determined for other parameters of exercise, including left ventricular power, 
      and the ratio of peak/resting VO(2) (cardiovascular reserve), the ratio of 
      peak/resting CO (cardiac reserve), and total peripheral vascular resistance. 
      CONCLUSION: Bioreactance-based noninvasive measurements of CO at rest and during 
      exertion identified abnormalities of cardiovascular function consistent with 
      those identified by pVO(2) and in prior studies using invasive CO measurements. 
      This technique might therefore be useful for indexing disease severity, 
      prognostication, and for tracking responses to treatment in clinical practice and 
      in clinical trials.
FAU - Maurer, Mathew M
AU  - Maurer MM
AD  - Division of Cardiology, Columbia University, New York, NY 10032, USA. 
      msm10@columbia.edu
FAU - Burkhoff, Daniel
AU  - Burkhoff D
FAU - Maybaum, Simon
AU  - Maybaum S
FAU - Franco, Veronica
AU  - Franco V
FAU - Vittorio, Timothy J
AU  - Vittorio TJ
FAU - Williams, Paula
AU  - Williams P
FAU - White, Leah
AU  - White L
FAU - Kamalakkannan, Gayathri
AU  - Kamalakkannan G
FAU - Myers, Jonathan
AU  - Myers J
FAU - Mancini, Donna M
AU  - Mancini DM
LA  - eng
GR  - IK6 RX002477/RX/RRD VA/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20090618
PL  - United States
TA  - J Card Fail
JT  - Journal of cardiac failure
JID - 9442138
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cardiac Output/*physiology
MH  - Cohort Studies
MH  - Exercise/*physiology
MH  - Exercise Test/instrumentation/*methods
MH  - Female
MH  - Heart Failure/diagnosis/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption/physiology
EDAT- 2009/09/30 06:00
MHDA- 2010/06/03 06:00
CRDT- 2009/09/30 06:00
PHST- 2008/09/13 00:00 [received]
PHST- 2009/04/15 00:00 [revised]
PHST- 2009/04/20 00:00 [accepted]
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2010/06/03 06:00 [medline]
AID - S1071-9164(09)00136-5 [pii]
AID - 10.1016/j.cardfail.2009.04.005 [doi]
PST - ppublish
SO  - J Card Fail. 2009 Oct;15(8):689-99. doi: 10.1016/j.cardfail.2009.04.005. Epub 
      2009 Jun 18.