PMID- 1978707
OWN - NLM
STAT- MEDLINE
DCOM- 19910103
LR  - 20190903
IS  - 0376-8716 (Print)
IS  - 0376-8716 (Linking)
VI  - 26
IP  - 2
DP  - 1990 Oct
TI  - Identification of metabolites of 3,4-methylenedioxymethamphetamine in rats.
PG  - 127-35
AB  - Liquid chromatography with electrochemical detection (LC/ECD) and gas 
      chromatography/mass spectrometry (GC/MS) were used to identify metabolites of 
      N-methyl-3,4-methylenedioxyamphetamine (MDMA) in samples of rat plasma and urine. 
      Several potential metabolites, based on what is known about the metabolism of the 
      desmethyl analog (i.e., MDA), were synthesized as standards to aid in the 
      identification of the MDMA metabolites. MDA and 
      N-methyl-1-(4-hydroxy-3-methoxy-phenyl)-2-aminopropane (3b) were identified in 
      urine by HPLC and confirmed by GC/MS. 
      1-(4-Hydroxy-3-methyoxyphenyl)2-aminopropane, (3a), 
      N-methyl-1-(3-hydroxy-4-methoxyphenyl)-2-aminopropane (2b) and 
      1-(3,4-dihydroxyphenyl)-2-aminopropane (4a) were tentatively identified by LC/ECD 
      but insufficient sample size precluded confirmation by mass spectrometry. MDA was 
      also identified in brain and plasma extracts. Because MDA is a metabolite of MDMA 
      in humans, and because it has been speculated that the neurotoxic effects of MDA 
      and MDMA may be due to a metabolite, the results of the present study may 
      ultimately aid our understanding of the neurotoxic mechanism of these drugs of 
      abuse.
FAU - Yousif, M Y
AU  - Yousif MY
AD  - Department of Medicinal Chemistry, School of Pharmacy, Medical College of 
      Virginia/Virginia Commonwealth University, Richmond 23298.
FAU - Fitzgerald, R L
AU  - Fitzgerald RL
FAU - Narasimhachari, N
AU  - Narasimhachari N
FAU - Rosecrans, J A
AU  - Rosecrans JA
FAU - Blanke, R V
AU  - Blanke RV
FAU - Glennon, R A
AU  - Glennon RA
LA  - eng
GR  - 5T32DA07027/DA/NIDA NIH HHS/United States
GR  - DA-01642/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Drug Alcohol Depend
JT  - Drug and alcohol dependence
JID - 7513587
RN  - 0 (Designer Drugs)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ML1I4KK67B (3,4-methylenedioxyethamphetamine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacokinetics
MH  - Animals
MH  - Chromatography, High Pressure Liquid
MH  - *Designer Drugs
MH  - Gas Chromatography-Mass Spectrometry
MH  - Inactivation, Metabolic/physiology
MH  - Injections, Subcutaneous
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Rats
MH  - Rats, Inbred Strains
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - 0376-8716(90)90119-Y [pii]
AID - 10.1016/0376-8716(90)90119-y [doi]
PST - ppublish
SO  - Drug Alcohol Depend. 1990 Oct;26(2):127-35. doi: 10.1016/0376-8716(90)90119-y.