PMID- 19787624
OWN - NLM
STAT- MEDLINE
DCOM- 20100408
LR  - 20221007
IS  - 0393-6155 (Print)
IS  - 0393-6155 (Linking)
VI  - 24
IP  - 3
DP  - 2009 Jul-Sep
TI  - Serum tumor necrosis factor-alpha and interleukin-2 concentrations in newly 
      diagnosed ERBB2 (HER2/neu) positive breast cancer patients.
PG  - 142-6
LID - 093085E8-FBBB-4240-ABA0-A3DADF102733 [pii]
AB  - AIM: Cytokines have been associated with symptoms and adverse outcomes in breast 
      cancer. Overexpression of ERBB2 (c-erb-b2; formerly HER2/neu), which is a member 
      of the epidermal growth receptor family, is associated with involvement of lymph 
      nodes, large tumor size, high grade, steroid receptor negativity, aneuploidy, 
      high proliferation rate, and low overall survival in breast cancer. The aim of 
      the study was to examine whether ERBB2 amplification has any effect on 
      circulating levels of tumor necrosis factor-alpha (TNF-alpha) and interleukin-2 
      (IL-2) in breast cancer patients. MATERIAL AND METHODS: Fifty patients with 
      primary breast carcinoma, classified as either ERBB2 (+) or (-) by the 
      fluorescence in situ hybridization (FISH) technique, were included in the study. 
      Cytokines were studied by ELISA according to the procedure described in the 
      commercial kit. RESULTS: IL-2 levels were found significantly higher in ERBB2+ 
      patients than in controls (p<0.05). A significant negative correlation existed 
      between ERBB2 positivity and estrogen receptor status (p=0.004). Plasma TNF-alpha 
      and IL-2 levels were positively correlated in ERBB2+ breast cancer patients 
      (p<0.01). CONCLUSION: The increase in IL-2 concentrations observed in our study 
      suggests an activation of T cells by ERBB2 peptides.
FAU - Saglam, Sezer
AU  - Saglam S
AD  - Department of Medical Oncology, Oncology Institute, Istanbul University, 
      Istanbul, Turkey.
FAU - Suzme, Rafi
AU  - Suzme R
FAU - Gurdol, Figen
AU  - Gurdol F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Biol Markers
JT  - The International journal of biological markers
JID - 8712411
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-2)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.10.1 (ERBB2 protein, human)
RN  - EC 2.7.10.1 (Receptor, ErbB-2)
SB  - IM
MH  - Breast Neoplasms/*blood/diagnosis/pathology
MH  - Cytokines/blood
MH  - Female
MH  - Humans
MH  - Interleukin-2/*blood
MH  - Neoplasm Staging
MH  - Receptor, ErbB-2/*blood
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2009/09/30 06:00
MHDA- 2010/04/09 06:00
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2010/04/09 06:00 [medline]
AID - 093085E8-FBBB-4240-ABA0-A3DADF102733 [pii]
AID - 10.1177/172460080902400303 [doi]
PST - ppublish
SO  - Int J Biol Markers. 2009 Jul-Sep;24(3):142-6. doi: 10.1177/172460080902400303.