PMID- 19787731
OWN - NLM
STAT- MEDLINE
DCOM- 20091217
LR  - 20211020
IS  - 1053-1807 (Print)
IS  - 1522-2586 (Electronic)
IS  - 1053-1807 (Linking)
VI  - 30
IP  - 4
DP  - 2009 Oct
TI  - Left ventricular infarct size, peri-infarct zone, and papillary scar 
      measurements: A comparison of high-resolution 3D and conventional 2D late 
      gadolinium enhancement cardiac MR.
PG  - 794-800
LID - 10.1002/jmri.21897 [doi]
AB  - PURPOSE: To compare higher spatial resolution 3D late gadolinium enhancement 
      (LGE) cardiovascular magnetic resonance (Cardiac MR) with 2D LGE in patients with 
      prior myocardial infarction. MATERIALS AND METHODS: Fourteen patients were 
      studied using high spatial resolution 3D LGE (1.3 x 1.3 x 5.0 mm(3)) and 
      conventional 2D LGE (2 x 2 x 8 mm(3)) scans. The signal-to-noise ratio (SNR) and 
      contrast-to-noise ratio (CNR) were measured. Total infarct volume, peri-infarct 
      volume measured in a limited slab, and papillary muscle scar volume were compared 
      using Bland-Altman analysis. Image quality was graded. RESULTS: 3D LGE had higher 
      scar SNR (P < 0.001), higher myocardial SNR (P = 0.001), higher papillary 
      scar-blood CNR (P = 0.01), and greater sharpness (P = 0.01). The scar volumes 
      agreed (14.5 +/- 8.2 for 2D, vs. 13.2 +/- 8.8 for 3D), with bias +/- 2 standard 
      deviations (SDs) of 0.5 +/- 6.8 mL, P = 0.59 R = 0.91. The peri-infarct volumes 
      correlated but less strongly than scar (P = 0.40, R = 0.77). For patients with 
      more heterogeneous scar, larger peri-infarct volumes were measured by 3D (1.9 +/- 
      1.1 mL for 2D vs. 2.4 +/- 1.6 mL for 3D, P = 0.15, in the matched region). 
      Papillary scar, present in 6/14 (42%) patients, was more confidently identified 
      on 3D LGE. CONCLUSION: Higher spatial resolution 3D LGE provides sharper images 
      and higher SNR, but less myocardial nulling. Scar volumes agree well, with 
      peri-infarct volumes correlating less well. 3D LGE may be superior in 
      visualization of papillary muscle scar.
CI  - (c) 2009 Wiley-Liss, Inc.
FAU - Peters, Dana C
AU  - Peters DC
AD  - Beth Israel Deaconess Medical Center, Department of Medicine (Cardiovascular 
      Division), Boston, Massachusetts, USA. dcpeters@bidmc.harvard.edu
FAU - Appelbaum, Evan A
AU  - Appelbaum EA
FAU - Nezafat, Reza
AU  - Nezafat R
FAU - Dokhan, Basem
AU  - Dokhan B
FAU - Han, Yuchi
AU  - Han Y
FAU - Kissinger, Kraig V
AU  - Kissinger KV
FAU - Goddu, Beth
AU  - Goddu B
FAU - Manning, Warren J
AU  - Manning WJ
LA  - eng
GR  - K01 EB004434/EB/NIBIB NIH HHS/United States
GR  - K01 EB004434-01A1/EB/NIBIB NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Magn Reson Imaging
JT  - Journal of magnetic resonance imaging : JMRI
JID - 9105850
RN  - 0 (Contrast Media)
RN  - K2I13DR72L (Gadolinium DTPA)
SB  - IM
MH  - Cicatrix/*pathology
MH  - Contrast Media
MH  - Female
MH  - Gadolinium DTPA
MH  - Humans
MH  - *Imaging, Three-Dimensional
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Phantoms, Imaging
MH  - Statistics, Nonparametric
MH  - Ventricular Dysfunction, Left/*pathology
PMC - PMC2981352
MID - NIHMS185663
EDAT- 2009/09/30 06:00
MHDA- 2009/12/18 06:00
PMCR- 2010/11/15
CRDT- 2009/09/30 06:00
PHST- 2009/09/30 06:00 [entrez]
PHST- 2009/09/30 06:00 [pubmed]
PHST- 2009/12/18 06:00 [medline]
PHST- 2010/11/15 00:00 [pmc-release]
AID - 10.1002/jmri.21897 [doi]
PST - ppublish
SO  - J Magn Reson Imaging. 2009 Oct;30(4):794-800. doi: 10.1002/jmri.21897.