PMID- 19788663
OWN - NLM
STAT- MEDLINE
DCOM- 20091028
LR  - 20160831
IS  - 1442-9071 (Electronic)
IS  - 1442-6404 (Linking)
VI  - 37
IP  - 7
DP  - 2009 Sep
TI  - Relationship between myopia and allergen-specific serum IgE levels in patients 
      with allergic conjunctivitis.
PG  - 670-7
LID - 10.1111/j.1442-9071.2009.02130.x [doi]
AB  - PURPOSE: Various exogenous allergens can cause allergic conjunctivitis, whereas 
      refractive errors are also related (as an endogenous factor) to the pathogenesis 
      of allergic conjunctivitis. However, little is known about the interaction 
      between exogenous and endogenous factors in patients with allergic 
      conjunctivitis. We investigated the relationship between refractive errors and 
      exogenous allergens in patients with allergic conjunctivitis. METHODS: Sixty 
      patients with allergic conjunctivitis and 60 healthy subjects (non-allergy 
      patients) were enrolled. Refraction was carried out in all subjects. In addition, 
      total immunoglobulin E (IgE) and specific IgE levels for 12 inhaled allergens 
      were measured by the capsulated hydrolic carrier polymer system. RESULTS: The 
      patients who were positive for-specific IgE to indoor allergens had higher myopia 
      than those who were negative, including those positive for house dust IgE (-3.66 
      +/- 2.95 vs. -1.05 +/- 3.39, P = 0.0015), Dermatophagoides pteronyssinus (D. 
      pteronyssinus) IgE (-3.50 +/- 2.91 vs. -1.01 +/- 3.46, P = 0.0021), and acarus 
      IgE (-3.45 +/- 2.21 vs. -1.51 +/- 3.73, P = 0.0087), whereas antibody-positive 
      and antibody-negative patients for outdoor allergens showed no significant 
      differences of refraction. Refractions in indoor group (-3.58 +/- 3.42) and 
      indoor/outdoor (-3.70 +/- 2.64) group were higher than those in outdoor group 
      (-0.84 +/- 2.30, P = 0.0047 and P = 0.0032) and the non-allergy group (-1.30 +/- 
      1.48, P = 0.0082 and P = 0.0054) [-refraction] was significantly correlated with 
      total IgE (r = 0.333, P = 0.0093), house dust (r = 0.355, P = 0.0054) and D. 
      pteronyssinus (r = 0.379, P = 0.0028), while no correlation between refractive 
      error and outdoor allergens was proven. CONCLUSION: These results suggest that 
      specific IgE levels for indoor allergens, such as house dust, might be associated 
      with refractive errors.
FAU - Mimura, Tatsuya
AU  - Mimura T
AD  - Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 
      7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. mimurat-tky@umin.ac.jp
FAU - Yamagami, Satoru
AU  - Yamagami S
FAU - Usui, Tomohiko
AU  - Usui T
FAU - Funatsu, Hideharu
AU  - Funatsu H
FAU - Noma, Hidetaka
AU  - Noma H
FAU - Honda, Norihiko
AU  - Honda N
FAU - Amano, Shiro
AU  - Amano S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Australia
TA  - Clin Exp Ophthalmol
JT  - Clinical & experimental ophthalmology
JID - 100896531
RN  - 0 (Allergens)
RN  - 0 (Antibodies)
RN  - 0 (Antigens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Allergens/*immunology
MH  - Animals
MH  - Antibodies/blood
MH  - Antigens/*immunology
MH  - Child
MH  - Conjunctivitis, Allergic/*immunology
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Male
MH  - Myopia/*immunology
MH  - Pyroglyphidae/immunology
MH  - Radioallergosorbent Test
MH  - Young Adult
EDAT- 2009/10/01 06:00
MHDA- 2009/10/29 06:00
CRDT- 2009/10/01 06:00
PHST- 2009/10/01 06:00 [entrez]
PHST- 2009/10/01 06:00 [pubmed]
PHST- 2009/10/29 06:00 [medline]
AID - CEO2130 [pii]
AID - 10.1111/j.1442-9071.2009.02130.x [doi]
PST - ppublish
SO  - Clin Exp Ophthalmol. 2009 Sep;37(7):670-7. doi: 10.1111/j.1442-9071.2009.02130.x.