PMID- 1979010
OWN - NLM
STAT- MEDLINE
DCOM- 19910116
LR  - 20220408
IS  - 0007-0912 (Print)
IS  - 0007-0912 (Linking)
VI  - 65
IP  - 4
DP  - 1990 Oct
TI  - Use of post-tetanic count in assessment of a repetitive vecuronium-induced 
      neuromuscular block.
PG  - 487-93
AB  - In order to evaluate the use of the post-tetanic count (PTC) method during 
      repetitive administration of vecuronium, we studied 20 patients allocated 
      randomly to one of two groups: 10 patients received droperidol-fentanyl 
      anaesthesia (control group); 10 other patients were given droperidol-fentanyl 
      anaesthesia modified subsequently by addition of 0.5% isoflurane (isoflurane 
      group). Before tracheal intubation, a bolus dose of vecuronium 0.08 mg kg-1 was 
      given i.v. followed by repeated doses of 0.03 mg kg-1. The twitch response of 
      adductor pollicis was recorded after supramaximal stimulation of the ulnar nerve 
      at the wrist using a Myograph 2000 neuromuscular transmission analyser. In the 
      control group, a close correlation was found between PTC and time to first 
      reaction to train-of-four (TOF) nerve stimulation. This relationship was 
      unchanged when comparing the bolus dose and each of eight consecutive maintenance 
      doses. Further, the degree and the duration of intense block were unchanged after 
      each of the eight maintenance doses. In the isoflurane group, the relationship 
      between PTC and time to first reaction to TOF stimulation remained unchanged 
      after addition of isoflurane. However, isoflurane caused a significant 
      prolongation of the duration of intense block and a corresponding lower PTC in 
      all patients. We conclude that PTC is a reliable method to evaluate intense 
      neuromuscular block caused by vecuronium, even after repetitive administration of 
      the drug and in combination with 0.5% isoflurane.
FAU - Eriksson, L I
AU  - Eriksson LI
AD  - Department of Anaesthesiology, University Hospital, Linkoping, Sweden.
FAU - Lennmarken, C
AU  - Lennmarken C
FAU - Staun, P
AU  - Staun P
FAU - Viby-Mogensen, J
AU  - Viby-Mogensen J
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Anaesth
JT  - British journal of anaesthesia
JID - 0372541
RN  - 7E4PHP5N1D (Vecuronium Bromide)
RN  - CYS9AKD70P (Isoflurane)
RN  - O9U0F09D5X (Droperidol)
RN  - UF599785JZ (Fentanyl)
SB  - IM
MH  - Adult
MH  - Anesthesia, General
MH  - Droperidol
MH  - Female
MH  - Fentanyl
MH  - Humans
MH  - Isoflurane
MH  - Male
MH  - Middle Aged
MH  - Muscle Contraction/*drug effects
MH  - Nerve Block/*methods
MH  - Neuromuscular Junction/*drug effects
MH  - Thumb/physiology
MH  - Time Factors
MH  - Ulnar Nerve/physiology
MH  - Vecuronium Bromide/administration & dosage/*pharmacology
EDAT- 1990/10/01 00:00
MHDA- 1990/10/01 00:01
CRDT- 1990/10/01 00:00
PHST- 1990/10/01 00:00 [pubmed]
PHST- 1990/10/01 00:01 [medline]
PHST- 1990/10/01 00:00 [entrez]
AID - S0007-0912(17)48352-8 [pii]
AID - 10.1093/bja/65.4.487 [doi]
PST - ppublish
SO  - Br J Anaesth. 1990 Oct;65(4):487-93. doi: 10.1093/bja/65.4.487.