PMID- 19793156
OWN - NLM
STAT- MEDLINE
DCOM- 20100224
LR  - 20220318
IS  - 1532-5415 (Electronic)
IS  - 0002-8614 (Print)
IS  - 0002-8614 (Linking)
VI  - 57
IP  - 11
DP  - 2009 Nov
TI  - Prediction of cardiorespiratory fitness in older men infected with the human 
      immunodeficiency virus: clinical factors and value of the six-minute walk 
      distance.
PG  - 2055-61
LID - 10.1111/j.1532-5415.2009.02495.x [doi]
AB  - OBJECTIVES: To investigate factors related to cardiorespiratory fitness in older 
      human immunodeficiency virus (HIV)-infected patients and to explore the utility 
      of 6-minute walk distance (6-MWD) in measuring fitness. DESIGN: Cross-sectional 
      study in clinic-based cohort. SETTING: Veterans Affairs Medical Center, 
      Baltimore, Maryland. PARTICIPANTS: Forty-three HIV-infected men, median age 57 
      (range 50-82), without recent acquired immunodeficiency syndrome-related illness 
      and receiving antiretroviral (ARV) therapy. MEASUREMENTS: Peak oxygen utilization 
      (VO(2)peak) according to treadmill graded exercise testing, 6-MWD, grip strength, 
      quadriceps maximum voluntary isometric contraction, cross-sectional area, muscle 
      quality, and muscle adiposity. RESULTS: There was a moderate correlation between 
      VO(2)peak (mean +/- SD; 18.4 +/- 5.6 mL/kg per minute) and 6-MWD (514 +/- 91 m) 
      (r=0.60, P<.001). VO(2)peak was lower in subjects with hypertension (16%, P<.01) 
      and moderate anemia (hemoglobin 10-13 gm/dL; 15%, P=.09) than in subjects without 
      these conditions. CD4 cell count (median 356 cells/mL, range 20-1,401) and HIV-1 
      viral load (84% nondetectable) were not related to VO(2)peak. Among muscle 
      parameters, only grip strength was an independent predictor of VO(2)peak. 
      Estimation of VO(2)peak using linear regression, including age, 6-MWD, grip 
      strength, and hypertension as independent variables, explained 61% of the 
      variance in VO(2)peak. CONCLUSION: Non-AIDS-related comorbidity predicts 
      cardiorespiratory fitness in older HIV-infected men receiving ARV therapy. The 
      6-MWD is a valuable measure of fitness in this patient population, but a larger 
      study with diverse subjects is needed.
FAU - Oursler, Krisann K
AU  - Oursler KK
AD  - Department of Medicine, School of Medicine, University of Maryland, Baltimore, 
      Maryland 21201, USA. koursler@grecc.umaryland.edu
FAU - Katzel, Leslie I
AU  - Katzel LI
FAU - Smith, Barbara A
AU  - Smith BA
FAU - Scott, Wayne B
AU  - Scott WB
FAU - Russ, David W
AU  - Russ DW
FAU - Sorkin, John D
AU  - Sorkin JD
LA  - eng
GR  - K23 AG024896/AG/NIA NIH HHS/United States
GR  - T32 HD041899/HD/NICHD NIH HHS/United States
GR  - T32 HD041899-01A1/HD/NICHD NIH HHS/United States
GR  - M01 RR 16500/RR/NCRR NIH HHS/United States
GR  - M01 RR016500/RR/NCRR NIH HHS/United States
GR  - P60-AG12583/AG/NIA NIH HHS/United States
GR  - K23 AG024896-03/AG/NIA NIH HHS/United States
GR  - R01 NR007980/NR/NINR NIH HHS/United States
GR  - P60 AG012583/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20090928
PL  - United States
TA  - J Am Geriatr Soc
JT  - Journal of the American Geriatrics Society
JID - 7503062
RN  - 0 (Anti-HIV Agents)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anemia/diagnosis/physiopathology
MH  - Anti-HIV Agents/therapeutic use
MH  - Baltimore
MH  - CD4 Lymphocyte Count
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - *Exercise Test
MH  - HIV Infections/*diagnosis/drug therapy/*physiopathology
MH  - Heart Rate/*physiology
MH  - Hospitals, Veterans
MH  - Humans
MH  - Isometric Contraction/*physiology
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/*physiology
MH  - Oxygen/*blood
MH  - Physical Fitness/*physiology
MH  - Risk Factors
MH  - Tidal Volume/*physiology
MH  - *Veterans
PMC - PMC3049945
MID - NIHMS232568
COIS- Conflict of Interest: The editor in chief has reviewed the conflict of interest 
      checklist provided by the authors and has determined that the authors have no 
      financial or any other kind of personal conflicts with this paper. Dr. Oursler's 
      effort on this research was supported by National Institutes of Health (NIH) 
      grant K23 AG024896. Dr. Scott's effort on this research was supported by a NIH 
      T32 grant. The research was supported by National Institute on Aging (NIA) 
      University of Maryland Claude D. Pepper Older Americans Independence Center 
      P60-AG12583 (Drs. Oursler, Katzel, Russ, and Sorkin), University of Maryland 
      General Clinical Research Center (M01 RR 16500), National Center for Research 
      Resources, National Center for Rehabilitation Research T32 HD041899-01A1 (Dr. 
      Scott), and Baltimore VA Geriatric Research, Clinical and Education Center (Drs. 
      Katzel and Sorkin).
EDAT- 2009/10/02 06:00
MHDA- 2010/02/25 06:00
PMCR- 2011/03/08
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/02/25 06:00 [medline]
PHST- 2011/03/08 00:00 [pmc-release]
AID - JGS2495 [pii]
AID - 10.1111/j.1532-5415.2009.02495.x [doi]
PST - ppublish
SO  - J Am Geriatr Soc. 2009 Nov;57(11):2055-61. doi: 10.1111/j.1532-5415.2009.02495.x. 
      Epub 2009 Sep 28.