PMID- 19793338
OWN - NLM
STAT- MEDLINE
DCOM- 20100305
LR  - 20211020
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Print)
IS  - 0009-9104 (Linking)
VI  - 158
IP  - 3
DP  - 2009 Dec
TI  - Omega-3 polyunsaturated fatty acids ameliorate the severity of ileitis in the 
      senescence accelerated mice (SAM)P1/Yit mice model.
PG  - 325-33
LID - 10.1111/j.1365-2249.2009.04020.x [doi]
AB  - Clinical studies using omega-3 polyunsaturated fatty acids (omega3-PUFA) to 
      Crohn's disease (CD) are conflicting. Beneficial effects of dietary omega3-PUFA 
      intake in various experimental inflammatory bowel disease (IBD) models have been 
      reported. However, animal models of large intestinal inflammation have been used 
      in all previous studies, and the effect of omega3 fat in an animal model of small 
      intestinal inflammation has not been reported. We hypothesized that the effects 
      of omega3 fat are different between large and small intestine. The aim of this 
      study was to determine whether the direct effect of omega3 fat is beneficial for 
      small intestinal inflammation. Senescence accelerated mice (SAM)P1/Yit mice 
      showed remarkable inflammation of the terminal ileum spontaneously. The numbers 
      of F4/80-positive monocyte-macrophage cells as well as beta7-integrin-positive 
      lymphocytes in the intestinal mucosa were increased significantly compared with 
      those in the control mice (AKR-J mice). The area of mucosal addressin cell 
      adhesion molecule-1 (MAdCAM-1)-positive vessels was also increased. The degree of 
      expression levels of monocyte chemoattractant protein-1 (MCP-1), interleukin 
      (IL)-6 and interferon (IFN)-gamma mRNA were increased significantly compared with 
      those in the control mice. The feeding of two different kinds of omega3 fat 
      (fish-oil-rich and perilla-oil-rich diets) for 16 weeks to SAMP1/Yit mice 
      ameliorated inflammation of the terminal ileum significantly. In both the 
      omega3-fat-rich diet groups, enhanced infiltration of F4/80-positive 
      monocytes/macrophages in intestinal mucosa of SAMP1/Yit mice cells and the 
      increased levels of MCP-1, IL-6 and IFN-gamma mRNA expression were ameliorated 
      significantly compared with those in the control diet group. The results suggest 
      that omega3 fat is beneficial for small intestinal inflammation by inhibition of 
      monocyte recruitment to inflamed intestinal mucosa.
FAU - Matsunaga, H
AU  - Matsunaga H
AD  - Department of Internal Medicine, National Defense Medical College, Tokorozawa, 
      Saitama, Japan.
FAU - Hokari, R
AU  - Hokari R
FAU - Kurihara, C
AU  - Kurihara C
FAU - Okada, Y
AU  - Okada Y
FAU - Takebayashi, K
AU  - Takebayashi K
FAU - Okudaira, K
AU  - Okudaira K
FAU - Watanabe, C
AU  - Watanabe C
FAU - Komoto, S
AU  - Komoto S
FAU - Nakamura, M
AU  - Nakamura M
FAU - Tsuzuki, Y
AU  - Tsuzuki Y
FAU - Kawaguchi, A
AU  - Kawaguchi A
FAU - Nagao, S
AU  - Nagao S
FAU - Miura, S
AU  - Miura S
LA  - eng
PT  - Journal Article
DEP - 20090930
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Fish Oils)
RN  - 0 (Interleukin-6)
RN  - 0 (Madcam1 protein, mouse)
RN  - 0 (Mucoproteins)
RN  - 0 (Plant Oils)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
RN  - 68132-21-8 (perilla seed oil)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Aging, Premature/immunology/pathology
MH  - Animals
MH  - Body Weight/drug effects
MH  - CD4 Lymphocyte Count
MH  - Cell Adhesion Molecules/metabolism
MH  - Chemotaxis, Leukocyte/drug effects/immunology
MH  - Disease Models, Animal
MH  - Drug Evaluation, Preclinical/methods
MH  - Fatty Acids, Omega-3/*therapeutic use
MH  - Fish Oils/therapeutic use
MH  - Ileitis/*drug therapy/immunology/pathology
MH  - Ileum/immunology
MH  - Immunity, Mucosal/drug effects
MH  - Interferon-gamma/biosynthesis/genetics
MH  - Interleukin-6/biosynthesis/genetics
MH  - Intestinal Mucosa/immunology
MH  - Male
MH  - Mice
MH  - Mice, Inbred AKR
MH  - Monocytes/immunology
MH  - Mucoproteins
MH  - Plant Oils/therapeutic use
MH  - Reverse Transcriptase Polymerase Chain Reaction/methods
MH  - alpha-Linolenic Acid/therapeutic use
PMC - PMC2792829
EDAT- 2009/10/02 06:00
MHDA- 2010/03/06 06:00
PMCR- 2010/12/01
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/03/06 06:00 [medline]
PHST- 2010/12/01 00:00 [pmc-release]
AID - CEI4020 [pii]
AID - 10.1111/j.1365-2249.2009.04020.x [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2009 Dec;158(3):325-33. doi: 10.1111/j.1365-2249.2009.04020.x. 
      Epub 2009 Sep 30.