PMID- 19794302
OWN - NLM
STAT- MEDLINE
DCOM- 20100105
LR  - 20171116
IS  - 1538-2990 (Electronic)
IS  - 0002-9629 (Linking)
VI  - 338
IP  - 6
DP  - 2009 Dec
TI  - Metabolic syndrome and homocysteine level as predictors of the severity of 
      coronary artery disease in patients with carotid stenosis.
PG  - 447-52
LID - 10.1097/MAJ.0b013e3181ab1c96 [doi]
AB  - BACKGROUND: Coronary artery disease (CAD) is the most important cause of 
      mortality and morbidity in patients who have undergone carotid artery 
      endovascular or surgical intervention. Metabolic syndrome (MetS) and 
      hyperhomocysteinemia (HHCY) have been reported to be associated with CAD. 
      However, no study has investigated the association between MetS or HHCY and the 
      severity of CAD in patients with carotid stenosis. METHODS: Total of 148 
      consecutive patients with at least 1 side of the extracranial internal carotid 
      artery were enrolled. Further, on the basis of the results of coronary 
      angiography, the patients were divided into the CAD group (n = 85) and the 
      non-CAD group (n = 63). RESULTS: Multiple regression analysis revealed that CAD 
      was independently associated with HHCY (odds ratio: 4.07; 95% confidence 
      interval: 1.93-8.57; P < 0.0001) and MetS (odds ratio: 3.38; 95% confidence 
      interval: 1.56-7.29; P = 0.002). Furthermore, multivariate stepwise linear 
      regression revealed that the MetS score and total plasma homocysteine level were 
      significantly correlated with affected vessel number in CAD and the extent of 
      coronary atherosclerosis. CONCLUSIONS: MetS and HHCY can predict the presence of 
      CAD in patients with carotid stenosis. Furthermore, the MetS score and total 
      plasma homocysteine level are significantly associated with the extent of 
      coronary atherosclerosis.
FAU - Hsieh, Ming-Jer
AU  - Hsieh MJ
AD  - Department of Internal Medicine, Second Section of Cardiology, Chang Gung 
      Memorial Hospital, Linkou Medical Center, Chang Gung University College of 
      Medicine, Taoyuan, Taiwan.
FAU - Chen, Chun-Chi
AU  - Chen CC
FAU - Lee, Tsong-Hai
AU  - Lee TH
FAU - Lee, Cheng-Hung
AU  - Lee CH
FAU - Wen, Ming-Shien
AU  - Wen MS
FAU - Lin, Fun-Chung
AU  - Lin FC
FAU - Hsieh, I-Chang
AU  - Hsieh IC
FAU - Wu, Delon
AU  - Wu D
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Med Sci
JT  - The American journal of the medical sciences
JID - 0370506
RN  - 0LVT1QZ0BA (Homocysteine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carotid Stenosis/*complications/diagnostic imaging
MH  - Coronary Angiography
MH  - Coronary Artery Disease/*complications/diagnostic imaging/etiology
MH  - Female
MH  - Homocysteine/*blood
MH  - Humans
MH  - Hyperhomocysteinemia/blood/complications
MH  - Male
MH  - Metabolic Syndrome/*blood/*complications
MH  - Middle Aged
MH  - Risk Factors
EDAT- 2009/10/02 06:00
MHDA- 2010/01/06 06:00
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/01/06 06:00 [medline]
AID - S0002-9629(15)31740-7 [pii]
AID - 10.1097/MAJ.0b013e3181ab1c96 [doi]
PST - ppublish
SO  - Am J Med Sci. 2009 Dec;338(6):447-52. doi: 10.1097/MAJ.0b013e3181ab1c96.