PMID- 19794982
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20211020
IS  - 1598-6357 (Electronic)
IS  - 1011-8934 (Print)
IS  - 1011-8934 (Linking)
VI  - 24
IP  - 5
DP  - 2009 Oct
TI  - Effects of chemical sympathectomy on contralateral testicular histology and 
      fertility in unilateral vasectomy.
PG  - 849-52
LID - 10.3346/jkms.2009.24.5.849 [doi]
AB  - Unilateral obstruction or injury to the vas deferens can result in significant 
      injury to the contralateral testicle. Although various pathways have been 
      proposed, the mechanism of contralateral testicular deterioration remains 
      controversial. The present animal study was performed to evaluate the effects of 
      unilateral vasectomy on ipsilateral and contralateral testicular histology and 
      fertility in rats that were chemically sympathectomized neonatally. The study 
      comprised 40 male albino rats: 20 received a placebo and the other 20 underwent 
      chemical sympathectomy neonatally. When 60 days old, each group of 20 rats was 
      divided into two groups that underwent either a sham operation or an operation to 
      create unilateral left vasectomy. Eight weeks after surgery, each male rat was 
      housed with two known fertile female rats for 25 days, and then their testes were 
      harvested. Mean seminiferous tubular diameters (MSTD) and mean testicular biopsy 
      scores (MTBS) were determined for each testis. Although MSTD and MTBS were not 
      significantly different between groups, chemical sympathectomy prevented the 
      decrease in total fertility rates of the rats with unilateral left vasectomy in 
      our study. Prevention of this decrease by chemical sympathectomy suggests that 
      the sympathetic nervous system may play a role in the testicular degeneration 
      associated with vasectomy.
FAU - Kutlu, Omer
AU  - Kutlu O
AD  - Department of Urology, Akdeniz University, Faculty of Medicine, Antalya, Turkey.
FAU - Kocabiyik, Ali
AU  - Kocabiyik A
FAU - Koksal, Ismail Turker
AU  - Koksal IT
FAU - Guntekin, Erol
AU  - Guntekin E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090923
PL  - Korea (South)
TA  - J Korean Med Sci
JT  - Journal of Korean medical science
JID - 8703518
RN  - 8HW4YBZ748 (Oxidopamine)
SB  - IM
MH  - Animals
MH  - Female
MH  - Fertility/*drug effects
MH  - Male
MH  - Oxidopamine/toxicity
MH  - Rats
MH  - *Sympathectomy, Chemical
MH  - Testis/drug effects/*pathology
MH  - *Vasectomy
PMC - PMC2752767
OTO - NOTNLM
OT  - Fertility
OT  - Rats
OT  - Sympathectomy, Chemical
OT  - Testis
OT  - Vasectomy
EDAT- 2009/10/02 06:00
MHDA- 2010/01/28 06:00
PMCR- 2009/10/01
CRDT- 2009/10/02 06:00
PHST- 2008/06/20 00:00 [received]
PHST- 2008/09/29 00:00 [accepted]
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
PHST- 2009/10/01 00:00 [pmc-release]
AID - 10.3346/jkms.2009.24.5.849 [doi]
PST - ppublish
SO  - J Korean Med Sci. 2009 Oct;24(5):849-52. doi: 10.3346/jkms.2009.24.5.849. Epub 
      2009 Sep 23.