PMID- 1979517
OWN - NLM
STAT- MEDLINE
DCOM- 19910131
LR  - 20190613
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 526
IP  - 2
DP  - 1990 Sep 3
TI  - Effects of MDMA ('ecstasy') on firing rates of serotonergic, dopaminergic, and 
      noradrenergic neurons in the rat.
PG  - 203-6
AB  - 3,4-Methylenedioxymethamphetamine (MDMA), a non-hallucinogenic drug of abuse, 
      potently depressed firing rates of a subpopulation of serotonin neurons in the 
      dorsal and median raphe. High neurotoxic doses depressed those serotonin neurons 
      unresponsive to low doses. Noradrenaline neurons in the locus coeruleus were also 
      depressed by moderate doses. Dopamine neurons were unaffected. It is concluded 
      that MDMA's unique psychological effects are mediated through a subpopulation of 
      serotonergic and noradrenergic neurons, presumably through effects on release 
      mechanisms.
FAU - Piercey, M F
AU  - Piercey MF
AD  - CNS Research, Upjohn Company, Kalamazoo, MI 49001.
FAU - Lum, J T
AU  - Lum JT
FAU - Palmer, J R
AU  - Palmer JR
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Designer Drugs)
RN  - 333DO1RDJY (Serotonin)
RN  - 4764-17-4 (3,4-Methylenedioxyamphetamine)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - VTD58H1Z2X (Dopamine)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - 3,4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
MH  - Action Potentials/drug effects
MH  - Animals
MH  - Designer Drugs/*pharmacology
MH  - Dopamine/*physiology
MH  - Electrodes, Implanted
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine
MH  - Neurons/*drug effects
MH  - Norepinephrine/*physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Serotonin/*physiology
EDAT- 1990/09/03 00:00
MHDA- 1990/09/03 00:01
CRDT- 1990/09/03 00:00
PHST- 1990/09/03 00:00 [pubmed]
PHST- 1990/09/03 00:01 [medline]
PHST- 1990/09/03 00:00 [entrez]
AID - 0006-8993(90)91222-3 [pii]
AID - 10.1016/0006-8993(90)91222-3 [doi]
PST - ppublish
SO  - Brain Res. 1990 Sep 3;526(2):203-6. doi: 10.1016/0006-8993(90)91222-3.