PMID- 19795399
OWN - NLM
STAT- MEDLINE
DCOM- 20100127
LR  - 20221207
IS  - 1520-7560 (Electronic)
IS  - 1520-7552 (Print)
IS  - 1520-7552 (Linking)
VI  - 25
IP  - 8
DP  - 2009 Nov
TI  - Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse 
      populations-significant evidence for linkage on chromosome 4q in African 
      Americans: the Family Investigation of Nephropathy and Diabetes Research Group.
PG  - 740-7
LID - 10.1002/dmrr.1031 [doi]
AB  - BACKGROUND: Previous studies have shown that in addition to environmental 
      influences, type 2 diabetes mellitus (T2DM) has a strong genetic component. The 
      goal of the current study is to identify regions of linkage for T2DM in 
      ethnically diverse populations. METHODS: Phenotypic and genotypic data were 
      obtained from African American (AA; total number of individuals [N] = 1004), 
      American Indian (AI; N = 883), European American (EA; N = 537), and Mexican 
      American (MA; N = 1634) individuals from the Family Investigation of Nephropathy 
      and Diabetes. Non-parametric linkage analysis, using an average of 4404 SNPs, was 
      performed in relative pairs affected with T2DM in each ethnic group. In addition, 
      family-based tests were performed to detect association with T2DM. RESULTS: 
      Statistically significant evidence for linkage was observed on chromosome 4q21.1 
      (LOD = 3.13; genome-wide p = 0.04) in AA. In addition, a total of 11 regions 
      showed suggestive evidence for linkage (estimated at LOD > 1.71), with the 
      highest LOD scores on chromosomes 12q21.31 (LOD = 2.02) and 22q12.3 (LOD = 2.38) 
      in AA, 2p11.1 (LOD = 2.23) in AI, 6p12.3 (LOD = 2.77) in EA, and 13q21.1 (LOD = . 
      2.24) in MA. While no region overlapped across all ethnic groups, at least five 
      loci showing LOD > 1.71 have been identified in previously published studies. 
      CONCLUSIONS: The results from this study provide evidence for the presence of 
      genes affecting T2DM on chromosomes 4q, 12q, and 22q in AA; 6p in EA; 2p in AI; 
      and 13q in MA. The strong evidence for linkage on chromosome 4q in AA provides 
      important information given the paucity of diabetes genetic studies in this 
      population.
FAU - Malhotra, Alka
AU  - Malhotra A
AD  - National Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, 
      Arizona, USA.
FAU - Igo, Robert P Jr
AU  - Igo RP Jr
FAU - Thameem, Farook
AU  - Thameem F
FAU - Kao, W H Linda
AU  - Kao WH
FAU - Abboud, Hanna E
AU  - Abboud HE
FAU - Adler, Sharon G
AU  - Adler SG
FAU - Arar, Nedal H
AU  - Arar NH
FAU - Bowden, Donald W
AU  - Bowden DW
FAU - Duggirala, Ravindranath
AU  - Duggirala R
FAU - Freedman, Barry I
AU  - Freedman BI
FAU - Goddard, Katrina A B
AU  - Goddard KA
FAU - Ipp, Eli
AU  - Ipp E
FAU - Iyengar, Sudha K
AU  - Iyengar SK
FAU - Kimmel, Paul L
AU  - Kimmel PL
FAU - Knowler, William C
AU  - Knowler WC
FAU - Kohn, Orly
AU  - Kohn O
FAU - Leehey, David
AU  - Leehey D
FAU - Meoni, Lucy A
AU  - Meoni LA
FAU - Nelson, Robert G
AU  - Nelson RG
FAU - Nicholas, Susanne B
AU  - Nicholas SB
FAU - Parekh, Rulan S
AU  - Parekh RS
FAU - Rich, Stephen S
AU  - Rich SS
FAU - Chen, Yii-Der I
AU  - Chen YD
FAU - Saad, Mohammed F
AU  - Saad MF
FAU - Scavini, Marina
AU  - Scavini M
FAU - Schelling, Jeffrey R
AU  - Schelling JR
FAU - Sedor, John R
AU  - Sedor JR
FAU - Shah, Vallabh O
AU  - Shah VO
FAU - Taylor, Kent D
AU  - Taylor KD
FAU - Thornley-Brown, Denyse
AU  - Thornley-Brown D
FAU - Zager, Philip G
AU  - Zager PG
FAU - Horvath, Amanda
AU  - Horvath A
FAU - Hanson, Robert L
AU  - Hanson RL
CN  - Family Investigation of Nephropathy and Diabetes Research Group
LA  - eng
GR  - M01-RR-01346/RR/NCRR NIH HHS/United States
GR  - R01 DK059997-04/DK/NIDDK NIH HHS/United States
GR  - R01 DK067528/DK/NIDDK NIH HHS/United States
GR  - R01 DK072348-04/DK/NIDDK NIH HHS/United States
GR  - M01-RR-000080/RR/NCRR NIH HHS/United States
GR  - R01 DK059997/DK/NIDDK NIH HHS/United States
GR  - M01-RR-00827-29/RR/NCRR NIH HHS/United States
GR  - ImNIH/Intramural NIH HHS/United States
GR  - M01 RR000997/RR/NCRR NIH HHS/United States
GR  - U01 DK057292/DK/NIDDK NIH HHS/United States
GR  - M01 RR001346/RR/NCRR NIH HHS/United States
GR  - P41 RR003655/RR/NCRR NIH HHS/United States
GR  - N01HG65403/HG/NHGRI NIH HHS/United States
GR  - R01 DK067528-05/DK/NIDDK NIH HHS/United States
GR  - U01DK57292-05/DK/NIDDK NIH HHS/United States
GR  - M01-RR-00425/RR/NCRR NIH HHS/United States
GR  - RR03655/RR/NCRR NIH HHS/United States
GR  - R01 DK072348/DK/NIDDK NIH HHS/United States
GR  - M01 RR000425/RR/NCRR NIH HHS/United States
GR  - M01-RR-07122/RR/NCRR NIH HHS/United States
GR  - M01 RR007122/RR/NCRR NIH HHS/United States
GR  - M01 RR000827/RR/NCRR NIH HHS/United States
GR  - M01 RR000080/RR/NCRR NIH HHS/United States
GR  - U01 DK057292-06/DK/NIDDK NIH HHS/United States
GR  - M01-RR-00997/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PL  - England
TA  - Diabetes Metab Res Rev
JT  - Diabetes/metabolism research and reviews
JID - 100883450
SB  - IM
MH  - Adult
MH  - Black or African American/*genetics
MH  - Aged
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 4/*genetics
MH  - Diabetes Mellitus, Type 2/ethnology/etiology/*genetics
MH  - Family
MH  - Female
MH  - Genetic Linkage
MH  - *Genetic Predisposition to Disease
MH  - Genome-Wide Association Study
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Population Groups/genetics
MH  - Statistics as Topic
PMC - PMC2783577
MID - NIHMS141779
FIR - Iyengar, S K
IR  - Iyengar SK
FIR - Elston, R C
IR  - Elston RC
FIR - Goddard, K A B
IR  - Goddard KA
FIR - Olson, J M
IR  - Olson JM
FIR - Ialacci, S
IR  - Ialacci S
FIR - Fondran, J
IR  - Fondran J
FIR - Horvath, A
IR  - Horvath A
FIR - Igo, R Jr
IR  - Igo R Jr
FIR - Jun, G
IR  - Jun G
FIR - Kramp, K
IR  - Kramp K
FIR - Molineros, J
IR  - Molineros J
FIR - Quade, S R E
IR  - Quade SR
EDAT- 2009/10/02 06:00
MHDA- 2010/01/28 06:00
PMCR- 2010/11/01
CRDT- 2009/10/02 06:00
PHST- 2009/10/02 06:00 [entrez]
PHST- 2009/10/02 06:00 [pubmed]
PHST- 2010/01/28 06:00 [medline]
PHST- 2010/11/01 00:00 [pmc-release]
AID - 10.1002/dmrr.1031 [doi]
PST - ppublish
SO  - Diabetes Metab Res Rev. 2009 Nov;25(8):740-7. doi: 10.1002/dmrr.1031.