PMID- 19797812
OWN - NLM
STAT- MEDLINE
DCOM- 20091202
LR  - 20130418
IS  - 0971-5916 (Print)
IS  - 0971-5916 (Linking)
VI  - 130
IP  - 2
DP  - 2009 Aug
TI  - Cytogenetic study of myelodysplastic syndrome from India.
PG  - 155-9
AB  - BACKGROUND & OBJECTIVE: Myelodysplastic syndrome (MDS) represents a group of 
      clonal haematological disorders characterized by progressive cytopenia reflecting 
      defects in erythroid, myeloid and megakaryocytic maturation. The incidence of MDS 
      is more in older age groups and frequent chromosome abnormalities reported to be 
      monosomies 5 and 7. However, the data on cytogenetic changes in Indian MDS 
      patients are scanty. The present study was therefore undertaken to study the 
      aetiology and frequency of chromosomal changes in MDS patients, attending a 
      tertiary care hospital in Maharashtra, India. METHODS: The study was carried out 
      in 145 MDS patients for six years (2001-2006) at National Institute of 
      Immunohaematology (ICMR), and KEM Hospital, Mumbai, India. The patients were 
      diagnosed according to FAB and WHO classification. Cytogenetic study was carried 
      out using GTG-banding and fluorescence in situ hybridization (FISH) methods. 
      Statistical analysis was done with Chi(2) and Fisher's exact test. RESULTS: 
      Chromosomal abnormalities, including novel chromosome aberrations were detected 
      in 54.48 per cent MDS patients and frequency of chromosomal aberrations increased 
      with increase in age (> or = 30 yr). Among occupational exposure factors, 
      chromosomal aberrations significantly (P<0.05) associated with pesticides 
      exposure. INTERPRETATION & CONCLUSION: Our findings showed 54.48 per cent 
      chromosome abnormalities including novel chromosome aberrations in MDS patients 
      and these chromosome aberrations were increased with advancing age. In our series 
      a high frequency of younger population (53%) developed MDS, a detailed molecular 
      genetics and aetiological factors need to be studied.
FAU - Vundinti, Babu Rao
AU  - Vundinti BR
AD  - National Institute of Immunohaematology (ICMR), Mumbai, India.
FAU - Kerketta, Lily
AU  - Kerketta L
FAU - Jijina, Farah
AU  - Jijina F
FAU - Ghosh, K
AU  - Ghosh K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - India
TA  - Indian J Med Res
JT  - The Indian journal of medical research
JID - 0374701
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Animals
MH  - *Chromosome Aberrations/chemically induced
MH  - *Cytogenetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - India
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/chemically induced/*genetics
MH  - Occupational Exposure/adverse effects
EDAT- 2009/10/03 06:00
MHDA- 2009/12/16 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2009/12/16 06:00 [medline]
PST - ppublish
SO  - Indian J Med Res. 2009 Aug;130(2):155-9.