PMID- 19797842
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20190923
IS  - 0021-5082 (Print)
IS  - 0021-5082 (Linking)
VI  - 64
IP  - 4
DP  - 2009 Sep
TI  - [Tohoku study of child development and exposure assessment].
PG  - 749-58
AB  - Dioxins, polychlorinated biphenyls (PCBs), and organochlorine pesticides are 
      bioaccumulative chemicals that are considered to be toxic contaminants. These 
      chemicals are classified as persistent organic pollutants (POPs). We have started 
      a prospective cohort study to examine the effects of perinatal exposure to these 
      chemicals as well as methylmercury on neurobehavioral development in Japanese 
      children. In this article, the method and the consequence of exposure assessment 
      were described. The concentrations of POPs in maternal blood, cord blood, and 
      breast milk were determined by high-resolution gas chromatography-high-resolution 
      mass spectrometry. In breast milk samples, p,p'-DDE was the predominant 
      pollutant, total PCB and beta-HCH being the other major constituents. Mirex and 
      major toxaphenes were also detected in all samples even though these chemicals 
      have never been used in Japan. Simple correlation analysis showed high 
      correlations among the three sample materials, indicating that there was a high 
      degree of consistency of chemicals in the body. Major chemicals were also 
      intercorrelated with other chemicals in either of the three sample materials. 
      These findings indicate the presence of coexposure to multiple POPs. Multiple 
      regression analysis indicated that the concentrations of PCBs were affected by 
      the age of mother, parity, and maternal fish intake. These results are 
      informative in terms of considering the strategy to reduce the body burden of 
      POPs in females. The chemical analysis were performed by two different 
      institutes. Multiple regression analysis also showed that the result of chamical 
      analysis was affected significantly by the difference in analyzing institute. 
      This finding suggest the importance of consistency in chemical analysis and the 
      necessity for quality and accuracy control using reference materials.
FAU - Nakai, Kunihiko
AU  - Nakai K
AD  - Department of Environmental Health Sciences, Tohoku University Graduate School of 
      Medicine, Aoba-ku, Sendai, Japan. nakaik@ehs.med.tohoku.ac.jp
FAU - Nakamura, Tomoyuki
AU  - Nakamura T
FAU - Murata, Katsuyuki
AU  - Murata K
FAU - Satoh, Hiroshi
AU  - Satoh H
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
RN  - 0 (Dioxins)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Methylmercury Compounds)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Body Burden
MH  - Cohort Studies
MH  - Dioxins/toxicity
MH  - Environmental Pollutants/analysis/*toxicity
MH  - Female
MH  - Fetal Blood/chemistry
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Hydrocarbons, Chlorinated/toxicity
MH  - Infant, Newborn
MH  - Japan
MH  - Methylmercury Compounds/toxicity
MH  - Milk, Human/chemistry
MH  - Polychlorinated Biphenyls/toxicity
MH  - Pregnancy
MH  - Prospective Studies
EDAT- 2009/10/03 06:00
MHDA- 2011/09/09 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - JST.JSTAGE/jjh/64.749 [pii]
AID - 10.1265/jjh.64.749 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 2009 Sep;64(4):749-58. doi: 10.1265/jjh.64.749.