PMID- 19797845
OWN - NLM
STAT- MEDLINE
DCOM- 20110908
LR  - 20190923
IS  - 0021-5082 (Print)
IS  - 0021-5082 (Linking)
VI  - 64
IP  - 4
DP  - 2009 Sep
TI  - [Profile and issues of prospective birth cohort in Japan].
PG  - 774-81
AB  - Recently, the effects of environmental risk factors including chemical compounds 
      and parents' lifestyles on the health of the next generations have widely 
      gathered public concerns around the world because of the vulnerability of 
      children to such environmental risk factors. To elucidate the processes and 
      mechanisms of the effects in more detail, the authors started a prospective birth 
      cohort study, namely, the Hokkaido study of Environment and Children's Health in 
      Hokkaido, the northern area of Japan. The study consists of two cohorts: a 
      large-scale cohort throughout Hokkaido and a hospital-based small-scale cohort. 
      The former was established in 2003 in collaboration with forty obstetric 
      hospitals and clinics around Hokkaido to estimate the prevalence of congenital 
      malformations and investigate the association of congenital anomalies with 
      environmental risk factors in pregnant mothers at a background level. The latter 
      was lunched in 2002 at the time of enrollment of pregnant women recruited at an 
      obstetric hospital in Sapporo so as to examine the relationships of environmental 
      substances such as polychlorinated biphenyls (PCBs), dioxins, persistent organic 
      pollutants (POPs), and heavy metals with infants' and children's health outcomes 
      including birth size, neurobehavioral development, thyroid function, and 
      immunologic system. In the study of both cohorts, we attempt to determine the 
      role of gene polymorphism on the occurrence of adverse outcomes in infants and 
      children. Although the prospective cohort study with well-designed 
      epidemiological protocols may provide many scientific lines of evidence, many 
      human and financial resources are required to support the study until its 
      completion and maintain the biobanks as well as data banks. In Japan, it is 
      urgently necessary to establish a system that supports the implementation and 
      management of a cohort study.
FAU - Yuasa, Motoyuki
AU  - Yuasa M
AD  - Department of Public Health Sciences, Hokkaido University Graduate School of 
      Medicine, Kita-ku, Sapporo, Japan. m-yuasa@med.hokudai.ac.jp
FAU - Kishi, Reiko
AU  - Kishi R
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Cohort Studies
MH  - Congenital Abnormalities/*etiology
MH  - Environmental Pollutants/*toxicity
MH  - Female
MH  - Fetus/drug effects
MH  - Humans
MH  - Japan
MH  - Pregnancy
MH  - Prospective Studies
MH  - Risk Factors
EDAT- 2009/10/03 06:00
MHDA- 2011/09/09 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2011/09/09 06:00 [medline]
AID - JST.JSTAGE/jjh/64.774 [pii]
AID - 10.1265/jjh.64.774 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 2009 Sep;64(4):774-81. doi: 10.1265/jjh.64.774.