PMID- 19797975
OWN - NLM
STAT- MEDLINE
DCOM- 20100119
LR  - 20151119
IS  - 1558-2035 (Electronic)
IS  - 1558-2027 (Linking)
VI  - 10
IP  - 12
DP  - 2009 Dec
TI  - Low high-density lipoprotein predicts death in patients with mild left 
      ventricular dysfunction regardless of coronary atherosclerosis.
PG  - 898-905
LID - 10.2459/JCM.0b013e32832e6682 [doi]
AB  - OBJECTIVE: Low plasma high-density lipoprotein (HDL)-cholesterol is a major risk 
      factor for cardiovascular diseases. We investigated whether HDL-cholesterol 
      levels had a prognostic value in patients with mild left ventricular dysfunction, 
      irrespective of the presence of coronary disease. METHODS: The study included 686 
      consecutive patients hospitalized between January 2002 and December 2006 because 
      of left ventricular dysfunction. All patients completed a lipid profile and 
      underwent coronary angiography. Patients were followed for a mean period of 23 
      months, during which major events were recorded. RESULTS: Seventy-three percent 
      of patients were New York Heart Association (NYHA) class I-II, with the mean 
      values of left ventricular ejection fraction and left ventricular end-diastolic 
      diameter being, respectively, 36.3 +/- 8.6% and 58.3 +/- 7.9 mm. Half of the 
      patients (52%) had HDL values less than 40 mg/dl, 28% presented with HDL less 
      than 35 mg/dl. In multivariable analysis, patients with HDL-cholesterol 
      concentration less than 40 mg/dl showed higher risk for cumulative mortality (HR 
      1.77, P < 0.05) and for cardiac death (HR 2.06, P < 0.05). This higher risk was 
      also observed in patients with low HDL-cholesterol levels but without significant 
      coronary stenosis. The inclusion of the C-reactive protein (CRP) inflammation 
      marker into the model highly improved the power of death prediction. CONCLUSION: 
      In patients with left ventricular dysfunction, regardless of the presence of 
      coronary atherosclerosis, lower HDL-cholesterol was a strong and independent 
      predictor of both cardiac and all-cause death.
FAU - Sampietro, Tiziana
AU  - Sampietro T
AD  - CNR Institute of Clinical Physiology, Italy bScuola Superiore Sant'Anna, Pisa, 
      Italy. tizisamp@ifc.cnr.it
FAU - Bigazzi, Federico
AU  - Bigazzi F
FAU - Puntoni, Mariarita
AU  - Puntoni M
FAU - Minichilli, Fabrizio
AU  - Minichilli F
FAU - Landi, Patrizia
AU  - Landi P
FAU - Dal Pino, Beatrice
AU  - Dal Pino B
FAU - Carpeggiani, Clara
AU  - Carpeggiani C
FAU - L'Abbate, Antonio
AU  - L'Abbate A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Cardiovasc Med (Hagerstown)
JT  - Journal of cardiovascular medicine (Hagerstown, Md.)
JID - 101259752
RN  - 0 (Biomarkers)
RN  - 0 (Lipoproteins, HDL)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - C-Reactive Protein/metabolism
MH  - Coronary Artery Disease/*blood/complications/*mortality
MH  - Female
MH  - Humans
MH  - Italy/epidemiology
MH  - Lipoproteins, HDL/*blood
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Ventricular Dysfunction, Left/*blood/complications/*mortality
EDAT- 2009/10/03 06:00
MHDA- 2010/01/20 06:00
CRDT- 2009/10/03 06:00
PHST- 2009/10/03 06:00 [entrez]
PHST- 2009/10/03 06:00 [pubmed]
PHST- 2010/01/20 06:00 [medline]
AID - 10.2459/JCM.0b013e32832e6682 [doi]
PST - ppublish
SO  - J Cardiovasc Med (Hagerstown). 2009 Dec;10(12):898-905. doi: 
      10.2459/JCM.0b013e32832e6682.